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Mpox Virus: Its Molecular Evolution and Potential Impact on Viral Epidemiology.
Viruses. 2023 04 18; 15(4)V

Abstract

Mpox (previously known as monkeypox) is an infectious viral illness caused by the mpox virus (MPXV), an orthopoxvirus that belongs to the family Poxviridae. The symptoms of mpox in humans are similar to those of smallpox, although the mortality rate is lower. In recent years, the concern over a potential global pandemic has increased due to reports of mpox spreading across Africa and other parts of the world. Prior to this discovery, mpox was a rare zoonotic disease restricted to endemic regions of Western and Central Africa. The sudden emergence of MPXV cases in multiple regions has raised concerns about its natural evolution. This review aims to provide an overview of previously available information about MPXV, including its genome, morphology, hosts and reservoirs, and virus-host interaction and immunology, as well as to perform phylogenetic analysis on available MPXV genomes, with an emphasis on the evolution of the genome in humans as new cases emerge.

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Authors+Show Affiliations

Yu X
Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China. Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China. School of Life Sciences, Tsinghua University, Beijing 100084, China.
Shi H
Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China. Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China.
Cheng G
Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China. Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China. Institute of Pathogenic Organisms, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.

MeSH

HumansMonkeypox virusMonkeypoxPhylogenyEvolution, MolecularOrthopoxvirusRare Diseases

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

37112975

Citation

Yu, Xi, et al. "Mpox Virus: Its Molecular Evolution and Potential Impact On Viral Epidemiology." Viruses, vol. 15, no. 4, 2023.
Yu X, Shi H, Cheng G. Mpox Virus: Its Molecular Evolution and Potential Impact on Viral Epidemiology. Viruses. 2023;15(4).
Yu, X., Shi, H., & Cheng, G. (2023). Mpox Virus: Its Molecular Evolution and Potential Impact on Viral Epidemiology. Viruses, 15(4). https://doi.org/10.3390/v15040995
Yu X, Shi H, Cheng G. Mpox Virus: Its Molecular Evolution and Potential Impact On Viral Epidemiology. Viruses. 2023 04 18;15(4) PubMed PMID: 37112975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mpox Virus: Its Molecular Evolution and Potential Impact on Viral Epidemiology. AU - Yu,Xi, AU - Shi,Huicheng, AU - Cheng,Gong, Y1 - 2023/04/18/ PY - 2023/03/14/received PY - 2023/04/15/revised PY - 2023/04/17/accepted PY - 2023/5/1/medline PY - 2023/4/28/pubmed PY - 2023/4/28/entrez KW - epidemiology KW - molecular evolution KW - mpox virus JF - Viruses JO - Viruses VL - 15 IS - 4 N2 - Mpox (previously known as monkeypox) is an infectious viral illness caused by the mpox virus (MPXV), an orthopoxvirus that belongs to the family Poxviridae. The symptoms of mpox in humans are similar to those of smallpox, although the mortality rate is lower. In recent years, the concern over a potential global pandemic has increased due to reports of mpox spreading across Africa and other parts of the world. Prior to this discovery, mpox was a rare zoonotic disease restricted to endemic regions of Western and Central Africa. The sudden emergence of MPXV cases in multiple regions has raised concerns about its natural evolution. This review aims to provide an overview of previously available information about MPXV, including its genome, morphology, hosts and reservoirs, and virus-host interaction and immunology, as well as to perform phylogenetic analysis on available MPXV genomes, with an emphasis on the evolution of the genome in humans as new cases emerge. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/37112975/Mpox_Virus:_Its_Molecular_Evolution_and_Potential_Impact_on_Viral_Epidemiology_ DB - PRIME DP - Unbound Medicine ER -