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Deciphering the role of MitomiRs in cancer: A comprehensive review.
Mitochondrion. 2023 05; 70:118-130.M

Abstract

MicroRNAs (miRNAs) are short non-coding RNAs that regulate many metabolic and signal transduction pathways. The role of miRNAs, usually found in the cytoplasm, in regulating gene expression and cancer progression has been extensively studied in the last few decades. However, very recently, miRNAs were found to localize in the mitochondria. MiRNAs that specifically localize in the mitochondria and the cytoplasmic miRNAs associated with mitochondria that directly or indirectly modulate specific mitochondrial functions are termed as "mitomiRs". Although it is not clear about the origin of mitomiRs that are situated within mitochondria (nuclear or mitochondrial origin), it is evident that they have specific functions in modulating gene expression and regulating important mitochondrial metabolic pathways. Through this review, we aim to delineate the mechanisms by which mitomiRs alter mitochondrial metabolic pathways and influence the initiation and progression of cancer. We further discuss the functions of particular mitomiRs, which have been widely studied in the context of mitochondrial metabolism and oncogenic signaling pathways. Based on the current knowledge, we can conclude that mitomiRs contribute significantly to mitochondrial function and metabolic regulation, and that dysregulation of mitomiRs can aid the proliferation of cancer cells. Therefore, the less explored area of mitomiRs' biology can be an important topic of research investigation in the future for targeting cancer cells.

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Authors+Show Affiliations

Patel D
School of Biotechnology, National Institute of Technology, Calicut-673601, Kerala, India.
Thankachan S
School of Biotechnology, National Institute of Technology, Calicut-673601, Kerala, India.
Abu Fawaz PP
Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipa1-576104, Karnataka, India.
Venkatesh T
Department of Biochemistry and Molecular Biology, Central University of Kerala, Kasaragod, Kerala 671316, India.
Prasada Kabekkodu S
Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipa1-576104, Karnataka, India.
Suresh PS
School of Biotechnology, National Institute of Technology, Calicut-673601, Kerala, India. Electronic address: sureshps@nitc.ac.in.

MeSH

HumansGene Expression RegulationMicroRNAsMitochondriaNeoplasmsSignal Transduction

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

37120081

Citation

Patel, Dimple, et al. "Deciphering the Role of MitomiRs in Cancer: a Comprehensive Review." Mitochondrion, vol. 70, 2023, pp. 118-130.
Patel D, Thankachan S, Abu Fawaz PP, et al. Deciphering the role of MitomiRs in cancer: A comprehensive review. Mitochondrion. 2023;70:118-130.
Patel, D., Thankachan, S., Abu Fawaz, P. P., Venkatesh, T., Prasada Kabekkodu, S., & Suresh, P. S. (2023). Deciphering the role of MitomiRs in cancer: A comprehensive review. Mitochondrion, 70, 118-130. https://doi.org/10.1016/j.mito.2023.04.004
Patel D, et al. Deciphering the Role of MitomiRs in Cancer: a Comprehensive Review. Mitochondrion. 2023;70:118-130. PubMed PMID: 37120081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deciphering the role of MitomiRs in cancer: A comprehensive review. AU - Patel,Dimple, AU - Thankachan,Sanu, AU - Abu Fawaz,P P, AU - Venkatesh,Thejaswini, AU - Prasada Kabekkodu,Shama, AU - Suresh,Padmanaban S, Y1 - 2023/04/28/ PY - 2023/01/08/received PY - 2023/04/01/revised PY - 2023/04/23/accepted PY - 2023/5/22/medline PY - 2023/4/30/pubmed PY - 2023/4/29/entrez KW - Cancer KW - Metabolism KW - Mitochondria KW - mitomiRs SP - 118 EP - 130 JF - Mitochondrion JO - Mitochondrion VL - 70 N2 - MicroRNAs (miRNAs) are short non-coding RNAs that regulate many metabolic and signal transduction pathways. The role of miRNAs, usually found in the cytoplasm, in regulating gene expression and cancer progression has been extensively studied in the last few decades. However, very recently, miRNAs were found to localize in the mitochondria. MiRNAs that specifically localize in the mitochondria and the cytoplasmic miRNAs associated with mitochondria that directly or indirectly modulate specific mitochondrial functions are termed as "mitomiRs". Although it is not clear about the origin of mitomiRs that are situated within mitochondria (nuclear or mitochondrial origin), it is evident that they have specific functions in modulating gene expression and regulating important mitochondrial metabolic pathways. Through this review, we aim to delineate the mechanisms by which mitomiRs alter mitochondrial metabolic pathways and influence the initiation and progression of cancer. We further discuss the functions of particular mitomiRs, which have been widely studied in the context of mitochondrial metabolism and oncogenic signaling pathways. Based on the current knowledge, we can conclude that mitomiRs contribute significantly to mitochondrial function and metabolic regulation, and that dysregulation of mitomiRs can aid the proliferation of cancer cells. Therefore, the less explored area of mitomiRs' biology can be an important topic of research investigation in the future for targeting cancer cells. SN - 1872-8278 UR - https://www.unboundmedicine.com/medline/citation/37120081/Deciphering_the_role_of_MitomiRs_in_cancer:_A_comprehensive_review_ DB - PRIME DP - Unbound Medicine ER -