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Energy balance in low birth weight infants fed formula of high or low medium-chain triglyceride content.
J Pediatr. 1986 Jun; 108(6):964-71.JPed

Abstract

We tested the effect on energy balance of the partial substitution of medium-chain for long-chain triglycerides in the diet of growing low birth weight infants. Fifteen infants were studied in a randomized double-blind crossover clinical trial in which each infant was fed each of two formulas, which were of equal gross energy and protein content but differed in fat composition. The high medium-chain triglyceride (MCT) formula contained medium- and long-chain triglycerides in a weight/weight ratio of 46:54; in the low MCT formula the ratio was 4:96. The hypothesis tested was that under conditions of equal gross energy intake the two diets would differ in their digestible and metabolizable energy contents and would produce differences in the infants' rates of energy expenditure and energy storage. Gross energy intakes averaged 562 and 555 kJ/kg/day (134 and 133 kcal/kg/day) with the high and low MCT formulas, respectively. With each diet, coefficients of energy digestibility (0.93) and metabolizability (0.91) were identical; the rates of energy expenditure were 262 (high MCT) and 265 (low MCT) kJ/kg/day (63 kcal/kg/day for both diets), and of energy storage were 246 (high MCT) and 239 (low MCT) kJ/kg/day (59 and 57 kcal/day). These differences were not significant. There were also no significant differences between the two diets in coefficients of nitrogen retention (mean 0.70) or in rate of weight gain (mean 21.5 gm/kg/day). The use of high MCT content in infant formula neither provided a nutritional advantage in energy digestibility or metabolizability nor resulted in an increased rate of energy expenditure or of energy storage.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3712166

Citation

Whyte, R K., et al. "Energy Balance in Low Birth Weight Infants Fed Formula of High or Low Medium-chain Triglyceride Content." The Journal of Pediatrics, vol. 108, no. 6, 1986, pp. 964-71.
Whyte RK, Campbell D, Stanhope R, et al. Energy balance in low birth weight infants fed formula of high or low medium-chain triglyceride content. J Pediatr. 1986;108(6):964-71.
Whyte, R. K., Campbell, D., Stanhope, R., Bayley, H. S., & Sinclair, J. C. (1986). Energy balance in low birth weight infants fed formula of high or low medium-chain triglyceride content. The Journal of Pediatrics, 108(6), 964-71.
Whyte RK, et al. Energy Balance in Low Birth Weight Infants Fed Formula of High or Low Medium-chain Triglyceride Content. J Pediatr. 1986;108(6):964-71. PubMed PMID: 3712166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Energy balance in low birth weight infants fed formula of high or low medium-chain triglyceride content. AU - Whyte,R K, AU - Campbell,D, AU - Stanhope,R, AU - Bayley,H S, AU - Sinclair,J C, PY - 1986/6/1/pubmed PY - 1986/6/1/medline PY - 1986/6/1/entrez SP - 964 EP - 71 JF - The Journal of pediatrics JO - J. Pediatr. VL - 108 IS - 6 N2 - We tested the effect on energy balance of the partial substitution of medium-chain for long-chain triglycerides in the diet of growing low birth weight infants. Fifteen infants were studied in a randomized double-blind crossover clinical trial in which each infant was fed each of two formulas, which were of equal gross energy and protein content but differed in fat composition. The high medium-chain triglyceride (MCT) formula contained medium- and long-chain triglycerides in a weight/weight ratio of 46:54; in the low MCT formula the ratio was 4:96. The hypothesis tested was that under conditions of equal gross energy intake the two diets would differ in their digestible and metabolizable energy contents and would produce differences in the infants' rates of energy expenditure and energy storage. Gross energy intakes averaged 562 and 555 kJ/kg/day (134 and 133 kcal/kg/day) with the high and low MCT formulas, respectively. With each diet, coefficients of energy digestibility (0.93) and metabolizability (0.91) were identical; the rates of energy expenditure were 262 (high MCT) and 265 (low MCT) kJ/kg/day (63 kcal/kg/day for both diets), and of energy storage were 246 (high MCT) and 239 (low MCT) kJ/kg/day (59 and 57 kcal/day). These differences were not significant. There were also no significant differences between the two diets in coefficients of nitrogen retention (mean 0.70) or in rate of weight gain (mean 21.5 gm/kg/day). The use of high MCT content in infant formula neither provided a nutritional advantage in energy digestibility or metabolizability nor resulted in an increased rate of energy expenditure or of energy storage. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/3712166/Energy_balance_in_low_birth_weight_infants_fed_formula_of_high_or_low_medium_chain_triglyceride_content_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(86)80941-6 DB - PRIME DP - Unbound Medicine ER -