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A Bayesian method for the estimation of penetrance: application to mandibulofacial and frontonasal dysostoses.
Am J Med Genet. 1986 Jun; 24(2):231-46.AJ

Abstract

We describe a Bayesian method of estimating penetrance from genealogical data. It consists of calculating the likelihood of the data alone to make inferences about penetrance without sample space considerations. The method is applied to mandibulofacial dysostosis giving a penetrance of 0.908 with 0.95 credible interval of [0.809; 0.972] and to frontonasal dysostosis giving a penetrance of 0.670 with 0.95 credible interval of [0.457; 0.851].

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3717208

Citation

Rogatko, A, et al. "A Bayesian Method for the Estimation of Penetrance: Application to Mandibulofacial and Frontonasal Dysostoses." American Journal of Medical Genetics, vol. 24, no. 2, 1986, pp. 231-46.
Rogatko A, Pereira CA, Frota-Pessoa O. A Bayesian method for the estimation of penetrance: application to mandibulofacial and frontonasal dysostoses. Am J Med Genet. 1986;24(2):231-46.
Rogatko, A., Pereira, C. A., & Frota-Pessoa, O. (1986). A Bayesian method for the estimation of penetrance: application to mandibulofacial and frontonasal dysostoses. American Journal of Medical Genetics, 24(2), 231-46.
Rogatko A, Pereira CA, Frota-Pessoa O. A Bayesian Method for the Estimation of Penetrance: Application to Mandibulofacial and Frontonasal Dysostoses. Am J Med Genet. 1986;24(2):231-46. PubMed PMID: 3717208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Bayesian method for the estimation of penetrance: application to mandibulofacial and frontonasal dysostoses. AU - Rogatko,A, AU - Pereira,C A, AU - Frota-Pessoa,O, PY - 1986/6/1/pubmed PY - 1986/6/1/medline PY - 1986/6/1/entrez SP - 231 EP - 46 JF - American journal of medical genetics JO - Am J Med Genet VL - 24 IS - 2 N2 - We describe a Bayesian method of estimating penetrance from genealogical data. It consists of calculating the likelihood of the data alone to make inferences about penetrance without sample space considerations. The method is applied to mandibulofacial dysostosis giving a penetrance of 0.908 with 0.95 credible interval of [0.809; 0.972] and to frontonasal dysostosis giving a penetrance of 0.670 with 0.95 credible interval of [0.457; 0.851]. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/3717208/A_Bayesian_method_for_the_estimation_of_penetrance:_application_to_mandibulofacial_and_frontonasal_dysostoses_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0148-7299&date=1986&volume=24&issue=2&spage=231 DB - PRIME DP - Unbound Medicine ER -