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The effect of vegetarian diets on plasma lipid and platelet levels.
Arch Intern Med. 1986 Jun; 146(6):1193-7.AI

Abstract

Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This may be secondary to dietary effects of plasma lipids and lipoproteins, but platelets, which may also play a role, have also been observed to have aberrant functions in vegetarians. We measured plasma lipid and lipoprotein levels, platelet function, platelet fatty acid levels, and platelet active prostaglandins in ten strict vegetarians (vegans), 15 lactovegetarians, and 25 age- and sex-matched omnivorous controls. The most striking observations were a highly significant rise in platelet linoleic acid concentration and a decline in platelet arachidonic acid concentration in both vegetarian subgroups as compared with omnivorous controls. Serum thromboxane and prostacyclin levels as well as results of platelet aggregation studies did not differ among the groups tested. Cholesterol levels were significantly lower in both vegetarian groups as compared with controls, but plasma high- and low-density lipoprotein levels were lower only in the vegan subgroup as compared with omnivores. If diet produces these changes in platelet fatty acid and plasma lipid levels it may contribute to the decreased risk of coronary heart disease and possibly atherosclerosis in vegetarians.

Authors

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Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3718107

Citation

Fisher, M, et al. "The Effect of Vegetarian Diets On Plasma Lipid and Platelet Levels." Archives of Internal Medicine, vol. 146, no. 6, 1986, pp. 1193-7.
Fisher M, Levine PH, Weiner B, et al. The effect of vegetarian diets on plasma lipid and platelet levels. Arch Intern Med. 1986;146(6):1193-7.
Fisher, M., Levine, P. H., Weiner, B., Ockene, I. S., Johnson, B., Johnson, M. H., Natale, A. M., Vaudreuil, C. H., & Hoogasian, J. (1986). The effect of vegetarian diets on plasma lipid and platelet levels. Archives of Internal Medicine, 146(6), 1193-7.
Fisher M, et al. The Effect of Vegetarian Diets On Plasma Lipid and Platelet Levels. Arch Intern Med. 1986;146(6):1193-7. PubMed PMID: 3718107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of vegetarian diets on plasma lipid and platelet levels. AU - Fisher,M, AU - Levine,P H, AU - Weiner,B, AU - Ockene,I S, AU - Johnson,B, AU - Johnson,M H, AU - Natale,A M, AU - Vaudreuil,C H, AU - Hoogasian,J, PY - 1986/6/1/pubmed PY - 1986/6/1/medline PY - 1986/6/1/entrez SP - 1193 EP - 7 JF - Archives of internal medicine JO - Arch Intern Med VL - 146 IS - 6 N2 - Vegetarians have an apparent diminished risk for the development of ischemic coronary heart disease. This may be secondary to dietary effects of plasma lipids and lipoproteins, but platelets, which may also play a role, have also been observed to have aberrant functions in vegetarians. We measured plasma lipid and lipoprotein levels, platelet function, platelet fatty acid levels, and platelet active prostaglandins in ten strict vegetarians (vegans), 15 lactovegetarians, and 25 age- and sex-matched omnivorous controls. The most striking observations were a highly significant rise in platelet linoleic acid concentration and a decline in platelet arachidonic acid concentration in both vegetarian subgroups as compared with omnivorous controls. Serum thromboxane and prostacyclin levels as well as results of platelet aggregation studies did not differ among the groups tested. Cholesterol levels were significantly lower in both vegetarian groups as compared with controls, but plasma high- and low-density lipoprotein levels were lower only in the vegan subgroup as compared with omnivores. If diet produces these changes in platelet fatty acid and plasma lipid levels it may contribute to the decreased risk of coronary heart disease and possibly atherosclerosis in vegetarians. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/3718107/The_effect_of_vegetarian_diets_on_plasma_lipid_and_platelet_levels_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/146/pg/1193 DB - PRIME DP - Unbound Medicine ER -