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K+-induced motility and depolarization of cochlear hair cells. Direct evidence for a new pathophysiological mechanism in Ménière's disease.
Arch Otorhinolaryngol 1986; 243(2):108-11AO

Abstract

In addition to an endolymphatic hydrops in various models of Ménière's disease, ruptures of the membranes lining the endolymphatic spaces or massive changes in their biochemical permeability are believed to allow large amounts of potassium-rich endolymph to deluge the normally low [K+] perilymphatic fluid. Our clinic has shown that exposure of the lateral and basal membrane parts of living isolated outer hair cells to increasing concentrations of potassium ions resulted in a sustained reversible cellular depolarization. Furthermore, potassium intoxication was accompanied by a strictly longitudinal contraction of the hair cells present. This was followed by hair cell relaxation in the presence of artificial perilymph. These findings suggest a supplementary hypothesis for the clinical manifestations of Ménière's disease: the reversible hair cell depolarization can explain the sudden tinnitus and parts of the hearing loss incurred as well as presumably the vertigo experienced; the reversible longitudinal hair cell contraction induces an abnormal change of cochlear micromechanics, resulting in concomitant attacks of deafness and also possibly contributing to the tinnitus perceived.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3718321

Citation

Zenner, H P.. "K+-induced Motility and Depolarization of Cochlear Hair Cells. Direct Evidence for a New Pathophysiological Mechanism in Ménière's Disease." Archives of Oto-rhino-laryngology, vol. 243, no. 2, 1986, pp. 108-11.
Zenner HP. K+-induced motility and depolarization of cochlear hair cells. Direct evidence for a new pathophysiological mechanism in Ménière's disease. Arch Otorhinolaryngol. 1986;243(2):108-11.
Zenner, H. P. (1986). K+-induced motility and depolarization of cochlear hair cells. Direct evidence for a new pathophysiological mechanism in Ménière's disease. Archives of Oto-rhino-laryngology, 243(2), pp. 108-11.
Zenner HP. K+-induced Motility and Depolarization of Cochlear Hair Cells. Direct Evidence for a New Pathophysiological Mechanism in Ménière's Disease. Arch Otorhinolaryngol. 1986;243(2):108-11. PubMed PMID: 3718321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - K+-induced motility and depolarization of cochlear hair cells. Direct evidence for a new pathophysiological mechanism in Ménière's disease. A1 - Zenner,H P, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 108 EP - 11 JF - Archives of oto-rhino-laryngology JO - Arch Otorhinolaryngol VL - 243 IS - 2 N2 - In addition to an endolymphatic hydrops in various models of Ménière's disease, ruptures of the membranes lining the endolymphatic spaces or massive changes in their biochemical permeability are believed to allow large amounts of potassium-rich endolymph to deluge the normally low [K+] perilymphatic fluid. Our clinic has shown that exposure of the lateral and basal membrane parts of living isolated outer hair cells to increasing concentrations of potassium ions resulted in a sustained reversible cellular depolarization. Furthermore, potassium intoxication was accompanied by a strictly longitudinal contraction of the hair cells present. This was followed by hair cell relaxation in the presence of artificial perilymph. These findings suggest a supplementary hypothesis for the clinical manifestations of Ménière's disease: the reversible hair cell depolarization can explain the sudden tinnitus and parts of the hearing loss incurred as well as presumably the vertigo experienced; the reversible longitudinal hair cell contraction induces an abnormal change of cochlear micromechanics, resulting in concomitant attacks of deafness and also possibly contributing to the tinnitus perceived. SN - 0302-9530 UR - https://www.unboundmedicine.com/medline/citation/3718321/K+_induced_motility_and_depolarization_of_cochlear_hair_cells__Direct_evidence_for_a_new_pathophysiological_mechanism_in_Ménière's_disease_ L2 - https://medlineplus.gov/menieresdisease.html DB - PRIME DP - Unbound Medicine ER -