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Effects of a low-fat diet on plasma lipoprotein levels.
Arch Intern Med 1986; 146(8):1573-7AI

Abstract

Lowering the intake of fat to decrease serum cholesterol levels has unknown effects on the proportion of cholesterol in low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Twenty normolipidemic nonvegetarians were given dietary instruction and supervision in a low-fat, semivegetarian diet for three months. Mean consumption of total fat, saturated fat, and cholesterol decreased, whereas intake of carbohydrate increased significantly on a low-fat diet. Plasma LDL levels decreased by 18% and HDL levels by 7% from prestudy baseline levels. The LDL/HDL ratio declined by 11%. Plasma triglyceride levels and body weight were unchanged. In individual subjects, the decrements in consumption of saturated fat and the increments in ingestion of polyunsaturated fat were each significantly correlated with decreases in LDL. One year after the subjects had returned to a self-selected diet, levels of dietary saturated fat and cholesterol and the plasma LDL/HDL ratio remained significantly below prestudy levels. This study and others suggest that a low-fat, high-carbohydrate diet favorably affects the plasma LDL/HDL proportion by decreasing LDL on a percentage basis 2 1/2 to three times more than it decreases HDL.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3729638

Citation

Sacks, F M., et al. "Effects of a Low-fat Diet On Plasma Lipoprotein Levels." Archives of Internal Medicine, vol. 146, no. 8, 1986, pp. 1573-7.
Sacks FM, Handysides GH, Marais GE, et al. Effects of a low-fat diet on plasma lipoprotein levels. Arch Intern Med. 1986;146(8):1573-7.
Sacks, F. M., Handysides, G. H., Marais, G. E., Rosner, B., & Kass, E. H. (1986). Effects of a low-fat diet on plasma lipoprotein levels. Archives of Internal Medicine, 146(8), pp. 1573-7.
Sacks FM, et al. Effects of a Low-fat Diet On Plasma Lipoprotein Levels. Arch Intern Med. 1986;146(8):1573-7. PubMed PMID: 3729638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a low-fat diet on plasma lipoprotein levels. AU - Sacks,F M, AU - Handysides,G H, AU - Marais,G E, AU - Rosner,B, AU - Kass,E H, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 1573 EP - 7 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 146 IS - 8 N2 - Lowering the intake of fat to decrease serum cholesterol levels has unknown effects on the proportion of cholesterol in low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Twenty normolipidemic nonvegetarians were given dietary instruction and supervision in a low-fat, semivegetarian diet for three months. Mean consumption of total fat, saturated fat, and cholesterol decreased, whereas intake of carbohydrate increased significantly on a low-fat diet. Plasma LDL levels decreased by 18% and HDL levels by 7% from prestudy baseline levels. The LDL/HDL ratio declined by 11%. Plasma triglyceride levels and body weight were unchanged. In individual subjects, the decrements in consumption of saturated fat and the increments in ingestion of polyunsaturated fat were each significantly correlated with decreases in LDL. One year after the subjects had returned to a self-selected diet, levels of dietary saturated fat and cholesterol and the plasma LDL/HDL ratio remained significantly below prestudy levels. This study and others suggest that a low-fat, high-carbohydrate diet favorably affects the plasma LDL/HDL proportion by decreasing LDL on a percentage basis 2 1/2 to three times more than it decreases HDL. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/3729638/Effects_of_a_low_fat_diet_on_plasma_lipoprotein_levels_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/146/pg/1573 DB - PRIME DP - Unbound Medicine ER -