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Immunological enhancement by fat-soluble vitamins, minerals, and trace metals: a factor in cancer prevention.

Abstract

High intakes of some fat-soluble vitamin or trace metals have been associated with a decreased risk of cancer. A mechanism to help explain their anticancer action might be immunosuppression during deficiency or immuno-enhancement with high intakes. In vitro, retinol suppressed T-lymphocyte functions, whereas high dietary vitamin A enhanced macrophage functions. High intakes of vitamin E can enhance some anticancer, immune defenses. Selenium excess was not very suppressive of immune functions in vitro, but did retard tumor cell growth. Selenium and zinc deficiencies are associated with immunosuppression. Enhanced immune functions by high intakes of trace elements and vitamins provide a mechanism to explain in part the concomitant decreased cancer incidence.

Authors

Source

MeSH

Diet
Humans
Immune System
Minerals
Neoplasms
Risk
Selenium
Trace Elements
Vitamin A Deficiency
Vitamin E
Vitamins
Zinc

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3731196

Citation

Watson, R R.. "Immunological Enhancement By Fat-soluble Vitamins, Minerals, and Trace Metals: a Factor in Cancer Prevention." Cancer Detection and Prevention, vol. 9, no. 1-2, 1986, pp. 67-77.
Watson RR. Immunological enhancement by fat-soluble vitamins, minerals, and trace metals: a factor in cancer prevention. Cancer Detect Prev. 1986;9(1-2):67-77.
Watson, R. R. (1986). Immunological enhancement by fat-soluble vitamins, minerals, and trace metals: a factor in cancer prevention. Cancer Detection and Prevention, 9(1-2), pp. 67-77.
Watson RR. Immunological Enhancement By Fat-soluble Vitamins, Minerals, and Trace Metals: a Factor in Cancer Prevention. Cancer Detect Prev. 1986;9(1-2):67-77. PubMed PMID: 3731196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunological enhancement by fat-soluble vitamins, minerals, and trace metals: a factor in cancer prevention. A1 - Watson,R R, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 67 EP - 77 JF - Cancer detection and prevention JO - Cancer Detect. Prev. VL - 9 IS - 1-2 N2 - High intakes of some fat-soluble vitamin or trace metals have been associated with a decreased risk of cancer. A mechanism to help explain their anticancer action might be immunosuppression during deficiency or immuno-enhancement with high intakes. In vitro, retinol suppressed T-lymphocyte functions, whereas high dietary vitamin A enhanced macrophage functions. High intakes of vitamin E can enhance some anticancer, immune defenses. Selenium excess was not very suppressive of immune functions in vitro, but did retard tumor cell growth. Selenium and zinc deficiencies are associated with immunosuppression. Enhanced immune functions by high intakes of trace elements and vitamins provide a mechanism to explain in part the concomitant decreased cancer incidence. SN - 0361-090X UR - https://www.unboundmedicine.com/medline/citation/3731196/Immunological_enhancement_by_fat_soluble_vitamins_minerals_and_trace_metals:_a_factor_in_cancer_prevention_ L2 - https://medlineplus.gov/minerals.html DB - PRIME DP - Unbound Medicine ER -