Tags

Type your tag names separated by a space and hit enter

Autoregulation and regional blood flow of the dog during hemorrhagic shock.
Circ Shock. 1986; 19(3):245-55.CS

Abstract

In 42 anesthetized dogs, we studied autoregulation and regional blood flow in the adrenal gland during hemorrhagic hypotension at 70, 50, and 30 mmHg of mean arterial pressure and in trimethaphan camsylate (TMP)-induced hypotension at 50 mmHg. Blood flow was measured by nonradioactive microspheres. Renal blood flow was significantly reduced at 50 mmHg, but total adrenal blood flow did not significantly decrease until the blood pressure fell below 30 mmHg. The autoregulatory response was clearly different between the kidney and adrenal gland. Cortical blood flow decreased significantly at 50 mmHg, but medullary blood flow increased in contrast to the reduction of blood pressure below 70 mmHg and returned at 30 mmHg to the flow rate seen in normotensive control. TMP induced a similar response in the medulla to that at 50 mmHg of hemorrhagic hypotension, and atropine reversed this TMP-induced change. Opposite microvascular responses were observed during hypotension: medullary blood flow increased and cortical flow decreased. This medullary vascular response is considered to contribute to the maintenance of total adrenal blood flow during hemorrhagic hypotension.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3731400

Citation

Hamaji, M, et al. "Autoregulation and Regional Blood Flow of the Dog During Hemorrhagic Shock." Circulatory Shock, vol. 19, no. 3, 1986, pp. 245-55.
Hamaji M, Nakamura M, Izukura M, et al. Autoregulation and regional blood flow of the dog during hemorrhagic shock. Circ Shock. 1986;19(3):245-55.
Hamaji, M., Nakamura, M., Izukura, M., Nakaba, H., Hashimoto, T., Tanaka, Y., Tumori, T., Miyata, M., Kawashima, Y., & Harrison, T. S. (1986). Autoregulation and regional blood flow of the dog during hemorrhagic shock. Circulatory Shock, 19(3), 245-55.
Hamaji M, et al. Autoregulation and Regional Blood Flow of the Dog During Hemorrhagic Shock. Circ Shock. 1986;19(3):245-55. PubMed PMID: 3731400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoregulation and regional blood flow of the dog during hemorrhagic shock. AU - Hamaji,M, AU - Nakamura,M, AU - Izukura,M, AU - Nakaba,H, AU - Hashimoto,T, AU - Tanaka,Y, AU - Tumori,T, AU - Miyata,M, AU - Kawashima,Y, AU - Harrison,T S, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 245 EP - 55 JF - Circulatory shock JO - Circ Shock VL - 19 IS - 3 N2 - In 42 anesthetized dogs, we studied autoregulation and regional blood flow in the adrenal gland during hemorrhagic hypotension at 70, 50, and 30 mmHg of mean arterial pressure and in trimethaphan camsylate (TMP)-induced hypotension at 50 mmHg. Blood flow was measured by nonradioactive microspheres. Renal blood flow was significantly reduced at 50 mmHg, but total adrenal blood flow did not significantly decrease until the blood pressure fell below 30 mmHg. The autoregulatory response was clearly different between the kidney and adrenal gland. Cortical blood flow decreased significantly at 50 mmHg, but medullary blood flow increased in contrast to the reduction of blood pressure below 70 mmHg and returned at 30 mmHg to the flow rate seen in normotensive control. TMP induced a similar response in the medulla to that at 50 mmHg of hemorrhagic hypotension, and atropine reversed this TMP-induced change. Opposite microvascular responses were observed during hypotension: medullary blood flow increased and cortical flow decreased. This medullary vascular response is considered to contribute to the maintenance of total adrenal blood flow during hemorrhagic hypotension. SN - 0092-6213 UR - https://www.unboundmedicine.com/medline/citation/3731400/Autoregulation_and_regional_blood_flow_of_the_dog_during_hemorrhagic_shock_ DB - PRIME DP - Unbound Medicine ER -