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Secretion of gliadin antibody by coeliac jejunal mucosal biopsies cultured in vitro.
Clin Exp Immunol. 1986 Apr; 64(1):119-24.CE

Abstract

The role of gliadin antibodies in coeliac disease is unknown. We have investigated this by maintaining jejunal biopsies from control subjects, treated and untreated coeliac patients in organ culture for 24 h. The tissue culture supernatants were assayed by enzyme-linked immunosorbent assay (ELISA) for total IgG, IgM and IgA, anti-gliadin and casein antibodies. Jejunal biopsies from untreated coeliac patients secreted more total IgM and IgA but not IgG, than biopsies from control subjects: values for treated coeliac patients were similar to those from control subjects. There was increased secretion of IgG and IgM gliadin antibody, but not casein antibody, by jejunal biopsies from untreated coeliac patients compared with those from control subjects.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3731523

Citation

Ciclitira, P J., et al. "Secretion of Gliadin Antibody By Coeliac Jejunal Mucosal Biopsies Cultured in Vitro." Clinical and Experimental Immunology, vol. 64, no. 1, 1986, pp. 119-24.
Ciclitira PJ, Ellis HJ, Wood GM, et al. Secretion of gliadin antibody by coeliac jejunal mucosal biopsies cultured in vitro. Clin Exp Immunol. 1986;64(1):119-24.
Ciclitira, P. J., Ellis, H. J., Wood, G. M., Howdle, P. D., & Losowsky, M. S. (1986). Secretion of gliadin antibody by coeliac jejunal mucosal biopsies cultured in vitro. Clinical and Experimental Immunology, 64(1), 119-24.
Ciclitira PJ, et al. Secretion of Gliadin Antibody By Coeliac Jejunal Mucosal Biopsies Cultured in Vitro. Clin Exp Immunol. 1986;64(1):119-24. PubMed PMID: 3731523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Secretion of gliadin antibody by coeliac jejunal mucosal biopsies cultured in vitro. AU - Ciclitira,P J, AU - Ellis,H J, AU - Wood,G M, AU - Howdle,P D, AU - Losowsky,M S, PY - 1986/4/1/pubmed PY - 1986/4/1/medline PY - 1986/4/1/entrez SP - 119 EP - 24 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 64 IS - 1 N2 - The role of gliadin antibodies in coeliac disease is unknown. We have investigated this by maintaining jejunal biopsies from control subjects, treated and untreated coeliac patients in organ culture for 24 h. The tissue culture supernatants were assayed by enzyme-linked immunosorbent assay (ELISA) for total IgG, IgM and IgA, anti-gliadin and casein antibodies. Jejunal biopsies from untreated coeliac patients secreted more total IgM and IgA but not IgG, than biopsies from control subjects: values for treated coeliac patients were similar to those from control subjects. There was increased secretion of IgG and IgM gliadin antibody, but not casein antibody, by jejunal biopsies from untreated coeliac patients compared with those from control subjects. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/3731523/Secretion_of_gliadin_antibody_by_coeliac_jejunal_mucosal_biopsies_cultured_in_vitro_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3731523/ DB - PRIME DP - Unbound Medicine ER -