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Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances.
Mech Ageing Dev. 2023 Jul; 213:111838.MA

Abstract

MicroRNAs (miRNA) are a class of small non-coding RNA, roughly 21-22 nucleotides in length, which are master gene regulators. These miRNAs bind to the mRNA's 3' - untranslated region and regulate post-transcriptional gene regulation, thereby influencing various physiological and cellular processes. Another class of miRNAs known as mitochondrial miRNA (MitomiRs) has been found to either originate from the mitochondrial genome or be translocated directly into the mitochondria. Although the role of nuclear DNA encoded miRNA in the progression of various neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, etc. is well known, accumulating evidence suggests the possible role of deregulated mitomiRs in the progression of various neurodegenerative diseases with unknown mechanism. We have attempted to outline the current state of mitomiRs role in controlling mitochondrial gene expression and function through this review, paying particular attention to their contribution to neurological processes, their etiology, and their potential therapeutic use.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Saikia BJ
CSIR Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India.
Bhardwaj J
CSIR Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India.
Paul S
CSIR Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India.
Sharma S
CSIR Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India.
Neog A
CSIR Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, India.
Paul SR
CSIR Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, India.
Bk B
CSIR Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India. Electronic address: binukumarbk@gmail.com.

MeSH

HumansMicroRNAsNeurodegenerative DiseasesGene Expression RegulationMitochondriaAlzheimer DiseaseMitochondrial Diseases

Pub Type(s)

Review
Journal Article

Language

eng

PubMed ID

37329989

Citation

Saikia, Bhaskar Jyoti, et al. "Understanding the Roles and Regulation of Mitochondrial microRNAs (MitomiRs) in Neurodegenerative Diseases: Current Status and Advances." Mechanisms of Ageing and Development, vol. 213, 2023, p. 111838.
Saikia BJ, Bhardwaj J, Paul S, et al. Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances. Mech Ageing Dev. 2023;213:111838.
Saikia, B. J., Bhardwaj, J., Paul, S., Sharma, S., Neog, A., Paul, S. R., & Bk, B. (2023). Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances. Mechanisms of Ageing and Development, 213, 111838. https://doi.org/10.1016/j.mad.2023.111838
Saikia BJ, et al. Understanding the Roles and Regulation of Mitochondrial microRNAs (MitomiRs) in Neurodegenerative Diseases: Current Status and Advances. Mech Ageing Dev. 2023;213:111838. PubMed PMID: 37329989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances. AU - Saikia,Bhaskar Jyoti, AU - Bhardwaj,Juhi, AU - Paul,Sangita, AU - Sharma,Srishti, AU - Neog,Anindita, AU - Paul,Swaraj Ranjan, AU - Bk,Binukumar, Y1 - 2023/06/15/ PY - 2022/12/27/received PY - 2023/06/13/revised PY - 2023/06/13/accepted PY - 2023/7/10/medline PY - 2023/6/18/pubmed PY - 2023/6/17/entrez KW - Cognitive impairment KW - Mitochondria KW - Mitochondrial dysfunction KW - MitomiRs KW - Neurodegeneration KW - Oxidative phosphorylation system (OXPHOS) SP - 111838 EP - 111838 JF - Mechanisms of ageing and development JO - Mech Ageing Dev VL - 213 N2 - MicroRNAs (miRNA) are a class of small non-coding RNA, roughly 21-22 nucleotides in length, which are master gene regulators. These miRNAs bind to the mRNA's 3' - untranslated region and regulate post-transcriptional gene regulation, thereby influencing various physiological and cellular processes. Another class of miRNAs known as mitochondrial miRNA (MitomiRs) has been found to either originate from the mitochondrial genome or be translocated directly into the mitochondria. Although the role of nuclear DNA encoded miRNA in the progression of various neurological diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, etc. is well known, accumulating evidence suggests the possible role of deregulated mitomiRs in the progression of various neurodegenerative diseases with unknown mechanism. We have attempted to outline the current state of mitomiRs role in controlling mitochondrial gene expression and function through this review, paying particular attention to their contribution to neurological processes, their etiology, and their potential therapeutic use. SN - 1872-6216 UR - https://www.unboundmedicine.com/medline/citation/37329989/Understanding_the_roles_and_regulation_of_mitochondrial_microRNAs__MitomiRs__in_neurodegenerative_diseases:_Current_status_and_advances_ DB - PRIME DP - Unbound Medicine ER -