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Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations.
J Lipid Res. 1986 Mar; 27(3):227-35.JL

Abstract

ApoE phenotypes were determined in 615 unrelated Finnish individuals. The apoE gene frequencies observed (epsilon 2, 0.041; epsilon 3, 0.733; epsilon 4, 0.227) differ significantly from those in other populations. The frequency of the allele epsilon 2 was lower and that of epsilon 4 higher than in all other studied populations. Plasma lipids and apolipoproteins A-I, A-II and B were recorded in 207 of the typed subjects. By comparison with the most frequent homozygous apoE 3/3 phenotype, it was found that total cholesterol, LDL-cholesterol, and apoB concentrations were all markedly higher in apoE 4/4 and to a lesser degree in apoE 4/3 phenotypic groups. On the other hand, these lipid and apolipoprotein levels tended to be lower in E-2 heterozygotes. These data confirm and extend, in a different ethnic group, previous results of an effect of apoE genes on plasma lipoprotein concentrations. The data suggest that the apoE gene locus may be one factor responsible for the high LDL cholesterol concentrations in the Finnish population.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3734624

Citation

Ehnholm, C, et al. "Apolipoprotein E Polymorphism in the Finnish Population: Gene Frequencies and Relation to Lipoprotein Concentrations." Journal of Lipid Research, vol. 27, no. 3, 1986, pp. 227-35.
Ehnholm C, Lukka M, Kuusi T, et al. Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J Lipid Res. 1986;27(3):227-35.
Ehnholm, C., Lukka, M., Kuusi, T., Nikkilä, E., & Utermann, G. (1986). Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. Journal of Lipid Research, 27(3), 227-35.
Ehnholm C, et al. Apolipoprotein E Polymorphism in the Finnish Population: Gene Frequencies and Relation to Lipoprotein Concentrations. J Lipid Res. 1986;27(3):227-35. PubMed PMID: 3734624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. AU - Ehnholm,C, AU - Lukka,M, AU - Kuusi,T, AU - Nikkilä,E, AU - Utermann,G, PY - 1986/3/1/pubmed PY - 1986/3/1/medline PY - 1986/3/1/entrez SP - 227 EP - 35 JF - Journal of lipid research JO - J. Lipid Res. VL - 27 IS - 3 N2 - ApoE phenotypes were determined in 615 unrelated Finnish individuals. The apoE gene frequencies observed (epsilon 2, 0.041; epsilon 3, 0.733; epsilon 4, 0.227) differ significantly from those in other populations. The frequency of the allele epsilon 2 was lower and that of epsilon 4 higher than in all other studied populations. Plasma lipids and apolipoproteins A-I, A-II and B were recorded in 207 of the typed subjects. By comparison with the most frequent homozygous apoE 3/3 phenotype, it was found that total cholesterol, LDL-cholesterol, and apoB concentrations were all markedly higher in apoE 4/4 and to a lesser degree in apoE 4/3 phenotypic groups. On the other hand, these lipid and apolipoprotein levels tended to be lower in E-2 heterozygotes. These data confirm and extend, in a different ethnic group, previous results of an effect of apoE genes on plasma lipoprotein concentrations. The data suggest that the apoE gene locus may be one factor responsible for the high LDL cholesterol concentrations in the Finnish population. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/3734624/Apolipoprotein_E_polymorphism_in_the_Finnish_population:_gene_frequencies_and_relation_to_lipoprotein_concentrations_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&pmid=3734624 DB - PRIME DP - Unbound Medicine ER -