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Cobalamin and unsaturated transcobalamin values in pernicious anaemia: relation to treatment.
Scand J Haematol. 1986 May; 36(5):457-65.SJ

Abstract

27 patients with pernicious anaemia, followed for a long period, were consecutively treated with 3 different vitamin B12 preparations while, during intervening periods, no therapy was given until signs of B12 deficiency developed. The mean of the vitamin B12-free period lasted 400 d. Some patients were 'short-reactors' whereas others were 'long-reactors'. Some patients repeatedly revealed deficiency signs at cobalamin values greater than 200 pmol/l and others at values less than 50 pmol/l, pointing to individually different cut-off points for appearance of signs of deficiency. Hypersegmentation was the first sign in about 2/3, neuropathy in 1/3 and mucosal changes in about 1/10 of the patients. The same type of deficiency was repeatedly noted in the same patient. The daily decline of plasma cobalamin values decreased during the vitamin B12-free period. In perorally treated patients the unsaturated transcobalamin values showed an inverse relationship to the cobalamin values. Marked increases in unsaturated transcobalamin I values were noted in 4 of 16 patients treated with B12 injections, resulting in prolonged high cobalamin values and prolongation of the vitamin B12-free periods.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3738426

Citation

Magnus, E M.. "Cobalamin and Unsaturated Transcobalamin Values in Pernicious Anaemia: Relation to Treatment." Scandinavian Journal of Haematology, vol. 36, no. 5, 1986, pp. 457-65.
Magnus EM. Cobalamin and unsaturated transcobalamin values in pernicious anaemia: relation to treatment. Scand J Haematol. 1986;36(5):457-65.
Magnus, E. M. (1986). Cobalamin and unsaturated transcobalamin values in pernicious anaemia: relation to treatment. Scandinavian Journal of Haematology, 36(5), 457-65.
Magnus EM. Cobalamin and Unsaturated Transcobalamin Values in Pernicious Anaemia: Relation to Treatment. Scand J Haematol. 1986;36(5):457-65. PubMed PMID: 3738426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cobalamin and unsaturated transcobalamin values in pernicious anaemia: relation to treatment. A1 - Magnus,E M, PY - 1986/5/1/pubmed PY - 1986/5/1/medline PY - 1986/5/1/entrez SP - 457 EP - 65 JF - Scandinavian journal of haematology JO - Scand J Haematol VL - 36 IS - 5 N2 - 27 patients with pernicious anaemia, followed for a long period, were consecutively treated with 3 different vitamin B12 preparations while, during intervening periods, no therapy was given until signs of B12 deficiency developed. The mean of the vitamin B12-free period lasted 400 d. Some patients were 'short-reactors' whereas others were 'long-reactors'. Some patients repeatedly revealed deficiency signs at cobalamin values greater than 200 pmol/l and others at values less than 50 pmol/l, pointing to individually different cut-off points for appearance of signs of deficiency. Hypersegmentation was the first sign in about 2/3, neuropathy in 1/3 and mucosal changes in about 1/10 of the patients. The same type of deficiency was repeatedly noted in the same patient. The daily decline of plasma cobalamin values decreased during the vitamin B12-free period. In perorally treated patients the unsaturated transcobalamin values showed an inverse relationship to the cobalamin values. Marked increases in unsaturated transcobalamin I values were noted in 4 of 16 patients treated with B12 injections, resulting in prolonged high cobalamin values and prolongation of the vitamin B12-free periods. SN - 0036-553X UR - https://www.unboundmedicine.com/medline/citation/3738426/Cobalamin_and_unsaturated_transcobalamin_values_in_pernicious_anaemia:_relation_to_treatment_ DB - PRIME DP - Unbound Medicine ER -