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Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine.
Bull World Health Organ. 1979; 57(2):275-9.BW

Abstract

A single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. The rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects.

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Authors

Doberstyn EB
No affiliation info available
Phintuyothin P
No affiliation info available
Noeypatimanondh S
No affiliation info available
Teerakiartkamjorn C
No affiliation info available

MeSH

Clinical Trials as TopicDose-Response Relationship, DrugDrug EvaluationHumansMalariaPiperidinesPlasmodium falciparumPyrimethamineQuinolinesSulfadoxineSulfanilamidesTablets

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

373903

Citation

Doberstyn, E B., et al. "Single-dose Therapy of Falciparum Malaria With Mefloquine or Pyrimethamine-sulfadoxine." Bulletin of the World Health Organization, vol. 57, no. 2, 1979, pp. 275-9.
Doberstyn EB, Phintuyothin P, Noeypatimanondh S, et al. Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine. Bull World Health Organ. 1979;57(2):275-9.
Doberstyn, E. B., Phintuyothin, P., Noeypatimanondh, S., & Teerakiartkamjorn, C. (1979). Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine. Bulletin of the World Health Organization, 57(2), 275-9.
Doberstyn EB, et al. Single-dose Therapy of Falciparum Malaria With Mefloquine or Pyrimethamine-sulfadoxine. Bull World Health Organ. 1979;57(2):275-9. PubMed PMID: 373903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine. AU - Doberstyn,E B, AU - Phintuyothin,P, AU - Noeypatimanondh,S, AU - Teerakiartkamjorn,C, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 275 EP - 9 JF - Bulletin of the World Health Organization JO - Bull World Health Organ VL - 57 IS - 2 N2 - A single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. The rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/373903/Single_dose_therapy_of_falciparum_malaria_with_mefloquine_or_pyrimethamine_sulfadoxine_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/373903/ DB - PRIME DP - Unbound Medicine ER -