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Leukotriene D4 increases pulmonary vascular permeability and pressure by different mechanisms in the rabbit.
Am Rev Respir Dis. 1986 Aug; 134(2):229-32.AR

Abstract

We designed experiments to define the effects of leukotriene D4 (LTD4) in the rabbit lung and to determine whether or not these effects were due to the synthesis of cyclooxygenase products. Infusion of LTD4 (0.01, 0.03, and 0.10 microgram) into the rabbit pulmonary vasculature caused a dose-related increase in pulmonary arterial pressure and tracheal pressure. Pretreatment with FPL 55712 (38 microM), a leukotriene receptor antagonist, or indomethacin (10 micrograms/ml of perfusate) completely prevented the increase in tracheal and pulmonary arterial pressure. We also studied the effect of LTD4 on pulmonary vascular permeability by measuring lung weight gain at 4 levels of left atrial pressures (0, 5, 10, and 15 mmHg). Leukotriene D4 increased lung weight gain at all levels of left atrial pressure compared with that in the control group. Pretreatment with FPL 55712 completely inhibited the increase in vascular permeability caused by LTD4. Although pretreatment with indomethacin blocked the increase in tracheal and vascular pressure caused by LTD4, it did not prevent the increase in vascular permeability. We conclude that in the rabbit, LTD4 increases tracheal pressure, pulmonary arterial pressure, and pulmonary vascular permeability. Leukotriene D4 increases tracheal and pulmonary arterial pressure by stimulating the synthesis of cyclooxygenase products, and it increases vascular permeability through a mechanism that does not require the synthesis of cyclooxygenase products.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3740648

Citation

Farrukh, I S., et al. "Leukotriene D4 Increases Pulmonary Vascular Permeability and Pressure By Different Mechanisms in the Rabbit." The American Review of Respiratory Disease, vol. 134, no. 2, 1986, pp. 229-32.
Farrukh IS, Sciuto AM, Spannhake EW, et al. Leukotriene D4 increases pulmonary vascular permeability and pressure by different mechanisms in the rabbit. Am Rev Respir Dis. 1986;134(2):229-32.
Farrukh, I. S., Sciuto, A. M., Spannhake, E. W., Gurtner, G. H., & Michael, J. R. (1986). Leukotriene D4 increases pulmonary vascular permeability and pressure by different mechanisms in the rabbit. The American Review of Respiratory Disease, 134(2), 229-32.
Farrukh IS, et al. Leukotriene D4 Increases Pulmonary Vascular Permeability and Pressure By Different Mechanisms in the Rabbit. Am Rev Respir Dis. 1986;134(2):229-32. PubMed PMID: 3740648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leukotriene D4 increases pulmonary vascular permeability and pressure by different mechanisms in the rabbit. AU - Farrukh,I S, AU - Sciuto,A M, AU - Spannhake,E W, AU - Gurtner,G H, AU - Michael,J R, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 229 EP - 32 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 134 IS - 2 N2 - We designed experiments to define the effects of leukotriene D4 (LTD4) in the rabbit lung and to determine whether or not these effects were due to the synthesis of cyclooxygenase products. Infusion of LTD4 (0.01, 0.03, and 0.10 microgram) into the rabbit pulmonary vasculature caused a dose-related increase in pulmonary arterial pressure and tracheal pressure. Pretreatment with FPL 55712 (38 microM), a leukotriene receptor antagonist, or indomethacin (10 micrograms/ml of perfusate) completely prevented the increase in tracheal and pulmonary arterial pressure. We also studied the effect of LTD4 on pulmonary vascular permeability by measuring lung weight gain at 4 levels of left atrial pressures (0, 5, 10, and 15 mmHg). Leukotriene D4 increased lung weight gain at all levels of left atrial pressure compared with that in the control group. Pretreatment with FPL 55712 completely inhibited the increase in vascular permeability caused by LTD4. Although pretreatment with indomethacin blocked the increase in tracheal and vascular pressure caused by LTD4, it did not prevent the increase in vascular permeability. We conclude that in the rabbit, LTD4 increases tracheal pressure, pulmonary arterial pressure, and pulmonary vascular permeability. Leukotriene D4 increases tracheal and pulmonary arterial pressure by stimulating the synthesis of cyclooxygenase products, and it increases vascular permeability through a mechanism that does not require the synthesis of cyclooxygenase products. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/3740648/Leukotriene_D4_increases_pulmonary_vascular_permeability_and_pressure_by_different_mechanisms_in_the_rabbit_ L2 - https://www.atsjournals.org/doi/10.1164/arrd.1986.134.2.229?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -