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Hypocholesterolemic effect of gamma-linolenic acid as evening primrose oil in rats.
Ann Nutr Metab 1986; 30(5):289-99AN

Abstract

The hypocholesterolemic effect of polyunsaturated fatty acids was compared in male rats given high-cholesterol diets containing either evening primrose oil (EPO, linoleic plus gamma-linolenic), safflower oil (SFO, linoleic) or olive oil (OLO, low linoleic) at the 10% level. EPO with a phytosterol content of 1.47% was found to be more hypocholesterolemic than SFO (phytosterols 0.34%), and rats given EPO excreted more neutral (cholesterol and its metabolites) but not acidic steroids during the first 2 weeks of the feeding. Even when the phytosterol content of EPO and SFO was adjusted to be the same (0.67%), EPO was still more hypocholesterolemic than SFO but to a lesser extent, although fecal neutral steroid excretion was comparable in these two dietary fat regimens. The results indicate a significant hypocholesterolemic efficacy of gamma-linolenic acid.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3752928

Citation

Sugano, M, et al. "Hypocholesterolemic Effect of Gamma-linolenic Acid as Evening Primrose Oil in Rats." Annals of Nutrition & Metabolism, vol. 30, no. 5, 1986, pp. 289-99.
Sugano M, Ide T, Ishida T, et al. Hypocholesterolemic effect of gamma-linolenic acid as evening primrose oil in rats. Ann Nutr Metab. 1986;30(5):289-99.
Sugano, M., Ide, T., Ishida, T., & Yoshida, K. (1986). Hypocholesterolemic effect of gamma-linolenic acid as evening primrose oil in rats. Annals of Nutrition & Metabolism, 30(5), pp. 289-99.
Sugano M, et al. Hypocholesterolemic Effect of Gamma-linolenic Acid as Evening Primrose Oil in Rats. Ann Nutr Metab. 1986;30(5):289-99. PubMed PMID: 3752928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypocholesterolemic effect of gamma-linolenic acid as evening primrose oil in rats. AU - Sugano,M, AU - Ide,T, AU - Ishida,T, AU - Yoshida,K, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 289 EP - 99 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 30 IS - 5 N2 - The hypocholesterolemic effect of polyunsaturated fatty acids was compared in male rats given high-cholesterol diets containing either evening primrose oil (EPO, linoleic plus gamma-linolenic), safflower oil (SFO, linoleic) or olive oil (OLO, low linoleic) at the 10% level. EPO with a phytosterol content of 1.47% was found to be more hypocholesterolemic than SFO (phytosterols 0.34%), and rats given EPO excreted more neutral (cholesterol and its metabolites) but not acidic steroids during the first 2 weeks of the feeding. Even when the phytosterol content of EPO and SFO was adjusted to be the same (0.67%), EPO was still more hypocholesterolemic than SFO but to a lesser extent, although fecal neutral steroid excretion was comparable in these two dietary fat regimens. The results indicate a significant hypocholesterolemic efficacy of gamma-linolenic acid. SN - 0250-6807 UR - https://www.unboundmedicine.com/medline/citation/3752928/Hypocholesterolemic_effect_of_gamma_linolenic_acid_as_evening_primrose_oil_in_rats_ L2 - https://www.karger.com?DOI=10.1159/000177206 DB - PRIME DP - Unbound Medicine ER -