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Effects of thromboxane synthase inhibition on air emboli lung injury in sheep.
J Appl Physiol (1985) 1986; 60(6):1828-33JA

Abstract

We tested the effects of OKY-046, a thromboxane synthase inhibitor, on lung injury induced by 2 h of pulmonary air infusion (1.23 ml/min) in the pulmonary artery of unanesthetized sheep with chronic lung lymph fistula so as to assess the role of thromboxane A2 (TxA2) in the lung injury. We measured pulmonary hemodynamic parameters and the lung fluid balance. The concentrations of thromboxane B2 (TxB2) and 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha) in plasma and lung lymph were determined by radioimmunoassay. Air infusion caused sustained pulmonary hypertension and an increase in pulmonary vascular permeability. The levels of TxB2 and 6-keto-PGF1 alpha in both plasma and lung lymph were significantly elevated during the air infusion. TxB2 concentration in plasma obtained from the left atrium was higher than that from the pulmonary artery at 15 min of air infusion. When sheep were pretreated with OKY-046 (10 mg/kg iv) prior to the air infusion, increases in TxB2 were prevented. The pulmonary arterial pressure, however, increased similarly to that of untreated sheep (1.8 X base line). The increase in lung lymph flow was significantly suppressed during the air infusion. Our data suggest that the pulmonary hypertension observed during air embolism is not caused by TxA2.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3755131

Citation

Fukushima, M, and T Kobayashi. "Effects of Thromboxane Synthase Inhibition On Air Emboli Lung Injury in Sheep." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 60, no. 6, 1986, pp. 1828-33.
Fukushima M, Kobayashi T. Effects of thromboxane synthase inhibition on air emboli lung injury in sheep. J Appl Physiol. 1986;60(6):1828-33.
Fukushima, M., & Kobayashi, T. (1986). Effects of thromboxane synthase inhibition on air emboli lung injury in sheep. Journal of Applied Physiology (Bethesda, Md. : 1985), 60(6), pp. 1828-33.
Fukushima M, Kobayashi T. Effects of Thromboxane Synthase Inhibition On Air Emboli Lung Injury in Sheep. J Appl Physiol. 1986;60(6):1828-33. PubMed PMID: 3755131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of thromboxane synthase inhibition on air emboli lung injury in sheep. AU - Fukushima,M, AU - Kobayashi,T, PY - 1986/6/1/pubmed PY - 1986/6/1/medline PY - 1986/6/1/entrez SP - 1828 EP - 33 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 60 IS - 6 N2 - We tested the effects of OKY-046, a thromboxane synthase inhibitor, on lung injury induced by 2 h of pulmonary air infusion (1.23 ml/min) in the pulmonary artery of unanesthetized sheep with chronic lung lymph fistula so as to assess the role of thromboxane A2 (TxA2) in the lung injury. We measured pulmonary hemodynamic parameters and the lung fluid balance. The concentrations of thromboxane B2 (TxB2) and 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha) in plasma and lung lymph were determined by radioimmunoassay. Air infusion caused sustained pulmonary hypertension and an increase in pulmonary vascular permeability. The levels of TxB2 and 6-keto-PGF1 alpha in both plasma and lung lymph were significantly elevated during the air infusion. TxB2 concentration in plasma obtained from the left atrium was higher than that from the pulmonary artery at 15 min of air infusion. When sheep were pretreated with OKY-046 (10 mg/kg iv) prior to the air infusion, increases in TxB2 were prevented. The pulmonary arterial pressure, however, increased similarly to that of untreated sheep (1.8 X base line). The increase in lung lymph flow was significantly suppressed during the air infusion. Our data suggest that the pulmonary hypertension observed during air embolism is not caused by TxA2. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/3755131/Effects_of_thromboxane_synthase_inhibition_on_air_emboli_lung_injury_in_sheep_ L2 - http://www.physiology.org/doi/full/10.1152/jappl.1986.60.6.1828?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -