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Clinical trial of six-month and four-month regimens of chemotherapy in the treatment of pulmonary tuberculosis.
Am Rev Respir Dis 1979; 119(4):579-85AR

Abstract

In a study in Singapore, Chinese, Malay, and Indian patients with pulmonary tuberculosis received 2 months of daily treatment with streptomycin, isoniazid, rifampin, and pyrazinamide followed either by daily treatment with isoniazid, rifampin, and pyrazinamide (SHRZ/HRZ regimen) or by daily administration of isoniazid and rifampin (SHRZ/HR regimen) allocated at random. Both regimens were given for either 6 or 4 months by random allocation. All 330 patients with drug-sensitive tubercle bacilli before treatment had a favorable bacteriologic response during chemotherapy. During the first 6 months after the end of chemotherapy, there was only a single bacteriologic relapse among 84 SHRZ/HRZ and 80 SHRZ/HR patients treated for 6 months, but 8 (10 per cent) of 80 SHRZ/HRZ and 4 (5 per cent) of 74 SHRZ/HR patients treated for 4 months relapsed. Of a total of 33 patients with bacilli resistant to isoniazid, streptomycin, or both drugs before treatment, only one had an unfavorable response during chemotherapy, and none of 31 patients relapsed during the first 6 months after stopping chemotherapy. The incidence of adverse reactions was low; 11 (3 per cent) of 397 patients had hepatitis, but not all episodes were attributable to drug toxicity, and one patient had thrombocytopenic purpura.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

375787

Citation

"Clinical Trial of Six-month and Four-month Regimens of Chemotherapy in the Treatment of Pulmonary Tuberculosis." The American Review of Respiratory Disease, vol. 119, no. 4, 1979, pp. 579-85.
Clinical trial of six-month and four-month regimens of chemotherapy in the treatment of pulmonary tuberculosis. Am Rev Respir Dis. 1979;119(4):579-85.
(1979). Clinical trial of six-month and four-month regimens of chemotherapy in the treatment of pulmonary tuberculosis. The American Review of Respiratory Disease, 119(4), pp. 579-85.
Clinical Trial of Six-month and Four-month Regimens of Chemotherapy in the Treatment of Pulmonary Tuberculosis. Am Rev Respir Dis. 1979;119(4):579-85. PubMed PMID: 375787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical trial of six-month and four-month regimens of chemotherapy in the treatment of pulmonary tuberculosis. PY - 1979/4/1/pubmed PY - 1979/4/1/medline PY - 1979/4/1/entrez SP - 579 EP - 85 JF - The American review of respiratory disease JO - Am. Rev. Respir. Dis. VL - 119 IS - 4 N2 - In a study in Singapore, Chinese, Malay, and Indian patients with pulmonary tuberculosis received 2 months of daily treatment with streptomycin, isoniazid, rifampin, and pyrazinamide followed either by daily treatment with isoniazid, rifampin, and pyrazinamide (SHRZ/HRZ regimen) or by daily administration of isoniazid and rifampin (SHRZ/HR regimen) allocated at random. Both regimens were given for either 6 or 4 months by random allocation. All 330 patients with drug-sensitive tubercle bacilli before treatment had a favorable bacteriologic response during chemotherapy. During the first 6 months after the end of chemotherapy, there was only a single bacteriologic relapse among 84 SHRZ/HRZ and 80 SHRZ/HR patients treated for 6 months, but 8 (10 per cent) of 80 SHRZ/HRZ and 4 (5 per cent) of 74 SHRZ/HR patients treated for 4 months relapsed. Of a total of 33 patients with bacilli resistant to isoniazid, streptomycin, or both drugs before treatment, only one had an unfavorable response during chemotherapy, and none of 31 patients relapsed during the first 6 months after stopping chemotherapy. The incidence of adverse reactions was low; 11 (3 per cent) of 397 patients had hepatitis, but not all episodes were attributable to drug toxicity, and one patient had thrombocytopenic purpura. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/375787/Clinical_trial_of_six_month_and_four_month_regimens_of_chemotherapy_in_the_treatment_of_pulmonary_tuberculosis_ L2 - http://www.atsjournals.org/doi/full/10.1164/arrd.1979.119.4.579?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -