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Effects of zeranol and trenbolone acetate on testis function, live weight gain and carcass traits of bulls.
J Anim Sci 1986; 63(2):358-68JA

Abstract

The ability of zeranol and trenbolone acetate (trenbolone) to alter testis function, weight gain and carcass traits of young bulls was studied. In Exp. 1, the effects of age at initial zeranol implantation was determined. After a 235-d experimental period, sequential implantation (56-d intervals) beginning at 100 or 150 d of age had reduced testis growth (P less than .01), sperm production (P less than .01) and serum testosterone concentration in response to gonadotropin releasing hormone (GnRH; P less than .01). The 200-d age group was partially suppressed, while the 250-d age group was not affected. Body weights were similar to controls in all groups. In Exp. 2, bulls previously implanted with zeranol at 175 and 231 d of age received single implants of zeranol, trenbolone or trenbolone plus zeranol at approximately 300 d of age. At slaughter (135 d later), body weight and carcass characteristics in all treatments were similar to controls. However, trenbolone reduced sperm production (P less than .05), zeranol reduced sperm production and testes weight (P less than .05), but trenbolone plus zeranol was similar to controls. Mean testosterone response to GnRH was suppressed in all implant groups on d 65 (P less than .01), but only in trenbolone or trenbolone plus zeranol groups on d 112 (P less than .05). Results indicate that zeranol suppresses spermatogenesis and testosterone production if implanted before approximately 200 d of age. Reduction of endogenous testosterone without alteration of weight gain or carcass characteristics may be of benefit if behavioral or masculinity traits of bulls are altered. Also, it appears that no benefit is derived from implanting bulls with both trenbolone and zeranol.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3759674

Citation

Silcox, R W., et al. "Effects of Zeranol and Trenbolone Acetate On Testis Function, Live Weight Gain and Carcass Traits of Bulls." Journal of Animal Science, vol. 63, no. 2, 1986, pp. 358-68.
Silcox RW, Keeton JT, Johnson BH. Effects of zeranol and trenbolone acetate on testis function, live weight gain and carcass traits of bulls. J Anim Sci. 1986;63(2):358-68.
Silcox, R. W., Keeton, J. T., & Johnson, B. H. (1986). Effects of zeranol and trenbolone acetate on testis function, live weight gain and carcass traits of bulls. Journal of Animal Science, 63(2), pp. 358-68.
Silcox RW, Keeton JT, Johnson BH. Effects of Zeranol and Trenbolone Acetate On Testis Function, Live Weight Gain and Carcass Traits of Bulls. J Anim Sci. 1986;63(2):358-68. PubMed PMID: 3759674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of zeranol and trenbolone acetate on testis function, live weight gain and carcass traits of bulls. AU - Silcox,R W, AU - Keeton,J T, AU - Johnson,B H, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 358 EP - 68 JF - Journal of animal science JO - J. Anim. Sci. VL - 63 IS - 2 N2 - The ability of zeranol and trenbolone acetate (trenbolone) to alter testis function, weight gain and carcass traits of young bulls was studied. In Exp. 1, the effects of age at initial zeranol implantation was determined. After a 235-d experimental period, sequential implantation (56-d intervals) beginning at 100 or 150 d of age had reduced testis growth (P less than .01), sperm production (P less than .01) and serum testosterone concentration in response to gonadotropin releasing hormone (GnRH; P less than .01). The 200-d age group was partially suppressed, while the 250-d age group was not affected. Body weights were similar to controls in all groups. In Exp. 2, bulls previously implanted with zeranol at 175 and 231 d of age received single implants of zeranol, trenbolone or trenbolone plus zeranol at approximately 300 d of age. At slaughter (135 d later), body weight and carcass characteristics in all treatments were similar to controls. However, trenbolone reduced sperm production (P less than .05), zeranol reduced sperm production and testes weight (P less than .05), but trenbolone plus zeranol was similar to controls. Mean testosterone response to GnRH was suppressed in all implant groups on d 65 (P less than .01), but only in trenbolone or trenbolone plus zeranol groups on d 112 (P less than .05). Results indicate that zeranol suppresses spermatogenesis and testosterone production if implanted before approximately 200 d of age. Reduction of endogenous testosterone without alteration of weight gain or carcass characteristics may be of benefit if behavioral or masculinity traits of bulls are altered. Also, it appears that no benefit is derived from implanting bulls with both trenbolone and zeranol. SN - 0021-8812 UR - https://www.unboundmedicine.com/medline/citation/3759674/Effects_of_zeranol_and_trenbolone_acetate_on_testis_function_live_weight_gain_and_carcass_traits_of_bulls_ L2 - https://academic.oup.com/jas/article-lookup/doi/10.2527/jas1986.632358x DB - PRIME DP - Unbound Medicine ER -