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Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation.
Methods Mol Biol. 2023; 2682:159-173.MM

Abstract

Hendra and Nipah viruses are henipaviruses that have caused lethal human disease in Australia and Malaysia, Bangladesh, India, and the Philippines, respectively. These viruses are considered Category C pathogens by the US Centers for Disease Control. Nipah virus was recently placed on the World Health Organization Research and Development Blueprint Roadmaps for vaccine and therapeutic development. Given the infrequent and unpredictable nature of henipavirus outbreaks licensure of vaccines and therapeutics will likely require an animal model to demonstrate protective efficacy against henipavirus disease. Studies have shown that nonhuman primates are the most accurate model of human henipavirus disease and would be an important component of any application for licensure of a vaccine or antiviral drug under the US FDA Animal Rule. Nonhuman primate model selection and dosing are discussed regarding vaccine and therapeutic studies against henipaviruses.

Authors+Show Affiliations

Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA. chad.mire@usda.gov. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. chad.mire@usda.gov. National Bio- and Agro-defense Facility, Agricultural Research Services, United States Department of Agriculutre, Manhattan, NY, USA. chad.mire@usda.gov.Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

37610581

Citation

Mire, Chad E., et al. "Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation." Methods in Molecular Biology (Clifton, N.J.), vol. 2682, 2023, pp. 159-173.
Mire CE, Satterfield BA, Geisbert TW. Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation. Methods Mol Biol. 2023;2682:159-173.
Mire, C. E., Satterfield, B. A., & Geisbert, T. W. (2023). Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation. Methods in Molecular Biology (Clifton, N.J.), 2682, 159-173. https://doi.org/10.1007/978-1-0716-3283-3_12
Mire CE, Satterfield BA, Geisbert TW. Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation. Methods Mol Biol. 2023;2682:159-173. PubMed PMID: 37610581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonhuman Primate Models for Nipah and Hendra Virus Countermeasure Evaluation. AU - Mire,Chad E, AU - Satterfield,Benjamin A, AU - Geisbert,Thomas W, PY - 2023/8/24/medline PY - 2023/8/23/pubmed PY - 2023/8/23/entrez KW - African green monkey KW - Henipavirus KW - Treatment KW - Vaccination SP - 159 EP - 173 JF - Methods in molecular biology (Clifton, N.J.) JO - Methods Mol Biol VL - 2682 N2 - Hendra and Nipah viruses are henipaviruses that have caused lethal human disease in Australia and Malaysia, Bangladesh, India, and the Philippines, respectively. These viruses are considered Category C pathogens by the US Centers for Disease Control. Nipah virus was recently placed on the World Health Organization Research and Development Blueprint Roadmaps for vaccine and therapeutic development. Given the infrequent and unpredictable nature of henipavirus outbreaks licensure of vaccines and therapeutics will likely require an animal model to demonstrate protective efficacy against henipavirus disease. Studies have shown that nonhuman primates are the most accurate model of human henipavirus disease and would be an important component of any application for licensure of a vaccine or antiviral drug under the US FDA Animal Rule. Nonhuman primate model selection and dosing are discussed regarding vaccine and therapeutic studies against henipaviruses. SN - 1940-6029 UR - https://www.unboundmedicine.com/medline/citation/37610581/Nonhuman_Primate_Models_for_Nipah_and_Hendra_Virus_Countermeasure_Evaluation_ DB - PRIME DP - Unbound Medicine ER -