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Ferret Models for Henipavirus Infection.
Methods Mol Biol. 2023; 2682:205-217.MM

Abstract

Henipaviruses are emerging zoonotic viruses that can cause outbreaks of severe respiratory and neurological disease in humans and animals such as horses. The mechanism by which these viruses can cause disease remain largely unknown and to date there are no therapeutics or vaccines approved for use in humans. Nipah virus is listed on the World Health Organization R & D Blueprint list of epidemic threats. In order to advance the availability of effective therapeutics and vaccines and medicines that can be used to save lives and avert large scale crises, animal models are required which recapitulate the disease progression in humans. Ferrets are highly susceptible to infection with henipaviruses and develop both severe respiratory and neurological disease. Therefore, the ferret model is highly suitable for studies into both the pathogenesis of henipaviruses, as well as pre-clinical evaluation of intervention strategies.

Authors+Show Affiliations

Wageningen Bioveterinary Institute, Lelystad and Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands. Barry.rockx@wur.nl.Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

37610584

Citation

Rockx, Barry, and Chad E. Mire. "Ferret Models for Henipavirus Infection." Methods in Molecular Biology (Clifton, N.J.), vol. 2682, 2023, pp. 205-217.
Rockx B, Mire CE. Ferret Models for Henipavirus Infection. Methods Mol Biol. 2023;2682:205-217.
Rockx, B., & Mire, C. E. (2023). Ferret Models for Henipavirus Infection. Methods in Molecular Biology (Clifton, N.J.), 2682, 205-217. https://doi.org/10.1007/978-1-0716-3283-3_15
Rockx B, Mire CE. Ferret Models for Henipavirus Infection. Methods Mol Biol. 2023;2682:205-217. PubMed PMID: 37610584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ferret Models for Henipavirus Infection. AU - Rockx,Barry, AU - Mire,Chad E, PY - 2023/8/24/medline PY - 2023/8/23/pubmed PY - 2023/8/23/entrez KW - Ferret KW - Henipavirus KW - Treatment KW - Vaccination SP - 205 EP - 217 JF - Methods in molecular biology (Clifton, N.J.) JO - Methods Mol Biol VL - 2682 N2 - Henipaviruses are emerging zoonotic viruses that can cause outbreaks of severe respiratory and neurological disease in humans and animals such as horses. The mechanism by which these viruses can cause disease remain largely unknown and to date there are no therapeutics or vaccines approved for use in humans. Nipah virus is listed on the World Health Organization R & D Blueprint list of epidemic threats. In order to advance the availability of effective therapeutics and vaccines and medicines that can be used to save lives and avert large scale crises, animal models are required which recapitulate the disease progression in humans. Ferrets are highly susceptible to infection with henipaviruses and develop both severe respiratory and neurological disease. Therefore, the ferret model is highly suitable for studies into both the pathogenesis of henipaviruses, as well as pre-clinical evaluation of intervention strategies. SN - 1940-6029 UR - https://www.unboundmedicine.com/medline/citation/37610584/Ferret_Models_for_Henipavirus_Infection_ DB - PRIME DP - Unbound Medicine ER -