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Antibodies to gliadin by ELISA as a screening test for childhood celiac disease.
J Pediatr Gastroenterol Nutr 1986 Sep-Oct; 5(5):726-9JP

Abstract

The sera of 309 children who were subjected to jejunal biopsy were tested for antigliadin antibodies (AGA) with enzyme-linked immunosorbent assay (ELISA) in order to evaluate the usefulness of this test as a screening test for childhood celiac disease (CD). Thirty-one children had flat intestinal mucosa later confirmed to be due to CD. Ninety percent of these children had significantly elevated levels of IgA class AGA and 94% had significantly elevated levels of IgG class AGA as compared to standard references. Two hundred and seventy-eight children had normal villous structure. In this group, 37 children out of 271 (seven excluded because of selective IgA deficiency) had elevated levels of IgA class AGA, and 93 children out of 278 had elevated levels of IgG class AGA. We conclude that ELISA-AGA is suitable as a screening test for childhood CD.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3761105

Citation

Ståhlberg, M R., et al. "Antibodies to Gliadin By ELISA as a Screening Test for Childhood Celiac Disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 5, no. 5, 1986, pp. 726-9.
Ståhlberg MR, Savilahti E, Viander M. Antibodies to gliadin by ELISA as a screening test for childhood celiac disease. J Pediatr Gastroenterol Nutr. 1986;5(5):726-9.
Ståhlberg, M. R., Savilahti, E., & Viander, M. (1986). Antibodies to gliadin by ELISA as a screening test for childhood celiac disease. Journal of Pediatric Gastroenterology and Nutrition, 5(5), pp. 726-9.
Ståhlberg MR, Savilahti E, Viander M. Antibodies to Gliadin By ELISA as a Screening Test for Childhood Celiac Disease. J Pediatr Gastroenterol Nutr. 1986;5(5):726-9. PubMed PMID: 3761105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibodies to gliadin by ELISA as a screening test for childhood celiac disease. AU - Ståhlberg,M R, AU - Savilahti,E, AU - Viander,M, PY - 1986/9/1/pubmed PY - 1986/9/1/medline PY - 1986/9/1/entrez SP - 726 EP - 9 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 5 IS - 5 N2 - The sera of 309 children who were subjected to jejunal biopsy were tested for antigliadin antibodies (AGA) with enzyme-linked immunosorbent assay (ELISA) in order to evaluate the usefulness of this test as a screening test for childhood celiac disease (CD). Thirty-one children had flat intestinal mucosa later confirmed to be due to CD. Ninety percent of these children had significantly elevated levels of IgA class AGA and 94% had significantly elevated levels of IgG class AGA as compared to standard references. Two hundred and seventy-eight children had normal villous structure. In this group, 37 children out of 271 (seven excluded because of selective IgA deficiency) had elevated levels of IgA class AGA, and 93 children out of 278 had elevated levels of IgG class AGA. We conclude that ELISA-AGA is suitable as a screening test for childhood CD. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/3761105/Antibodies_to_gliadin_by_ELISA_as_a_screening_test_for_childhood_celiac_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3761105.ui DB - PRIME DP - Unbound Medicine ER -