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Effects of chlorine dioxide on thyroid function in the African green monkey and the rat.
J Toxicol Environ Health. 1986; 19(2):235-42.JT

Abstract

In a previous study from this laboratory, chlorine dioxide (ClO2) treated drinking water depressed thyroxine (T4) levels in the African green monkey. The present study again demonstrated a decrease in T4 levels in the same species after 4 wk of oral exposure. However, after 8 wk of treatment T4 levels rebounded to above pretreatment levels, coinciding with an increase in thyroid radioiodide uptake. This T4 rebound phenomenon and increased iodide uptake may be due to a compensatory endocrinological mechanism. In rats, T4 levels dropped during the 8-wk ClO2 treatment period in a dose-dependent manner, and no rebound effect was observed. Iodide uptake values in the rat were not affected. It appears that ClO2 may have an effect on thyroid function in both species.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3761383

Citation

Harrington, R M., et al. "Effects of Chlorine Dioxide On Thyroid Function in the African Green Monkey and the Rat." Journal of Toxicology and Environmental Health, vol. 19, no. 2, 1986, pp. 235-42.
Harrington RM, Shertzer HG, Bercz JP. Effects of chlorine dioxide on thyroid function in the African green monkey and the rat. J Toxicol Environ Health. 1986;19(2):235-42.
Harrington, R. M., Shertzer, H. G., & Bercz, J. P. (1986). Effects of chlorine dioxide on thyroid function in the African green monkey and the rat. Journal of Toxicology and Environmental Health, 19(2), 235-42.
Harrington RM, Shertzer HG, Bercz JP. Effects of Chlorine Dioxide On Thyroid Function in the African Green Monkey and the Rat. J Toxicol Environ Health. 1986;19(2):235-42. PubMed PMID: 3761383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of chlorine dioxide on thyroid function in the African green monkey and the rat. AU - Harrington,R M, AU - Shertzer,H G, AU - Bercz,J P, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 235 EP - 42 JF - Journal of toxicology and environmental health JO - J Toxicol Environ Health VL - 19 IS - 2 N2 - In a previous study from this laboratory, chlorine dioxide (ClO2) treated drinking water depressed thyroxine (T4) levels in the African green monkey. The present study again demonstrated a decrease in T4 levels in the same species after 4 wk of oral exposure. However, after 8 wk of treatment T4 levels rebounded to above pretreatment levels, coinciding with an increase in thyroid radioiodide uptake. This T4 rebound phenomenon and increased iodide uptake may be due to a compensatory endocrinological mechanism. In rats, T4 levels dropped during the 8-wk ClO2 treatment period in a dose-dependent manner, and no rebound effect was observed. Iodide uptake values in the rat were not affected. It appears that ClO2 may have an effect on thyroid function in both species. SN - 0098-4108 UR - https://www.unboundmedicine.com/medline/citation/3761383/Effects_of_chlorine_dioxide_on_thyroid_function_in_the_African_green_monkey_and_the_rat_ DB - PRIME DP - Unbound Medicine ER -