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Bioavailability of iron in soy-based formula and its effect on iron nutriture in infancy.
Pediatrics. 1986 Oct; 78(4):640-5.Ped

Abstract

Soy products have been reported to inhibit absorption of nonheme food iron and fortification iron. Iron bioavailability from a soy formula (Prosobee-PP 710) (iron added as ferrous sulfate: 12 mg/L; ascorbic acid: 54 mg/L) was examined in 16 adult women using the extrinsic radioactive tag method. The geometric mean absorption from the soy formula was only 1.7%. The effect of this formula on iron nutrition in infants was studied in 47 healthy term infants weaned spontaneously before 2 months of age and who received the formula ad libitum until 9 months of age. For control, 45 infants received a cow's milk formula fortified with ferrous sulfate (iron: 15 mg/L; ascorbic acid: 100 mg/L), which has been shown to be effective in preventing iron deficiency, and 49 additional breast-fed infants were also followed. All babies received solid foods (vegetables and meat) starting at 4 months of age. Iron nutritional status was determined at 9 months. Infants fed soy formula and iron-fortified cow's milk had similar mean values of hemoglobin, mean corpuscular volume, transferrin saturation, free erythrocyte protoporphyrin, and serum ferritin; both formula groups differed significantly (P less than .05) from the breast-fed group in all measurements except free erythrocyte protoporphyrin. Anemia (hemoglobin less than 11 g/dL) was present in only 4.3% and 2.2% of infants receiving the soy and the fortified formulas, respectively, v 27.3% in the breast-fed group. These results indicate that soy formula, in spite of the lower iron bioavailability when measured in adults, is essentially as effective as iron-fortified cow's milk in preventing iron deficiency in infants.

Authors

Hertrampf E
No affiliation info available
Cayazzo M
No affiliation info available
Pizarro F
No affiliation info available
Stekel A
No affiliation info available

MeSH

AdultAnemia, HypochromicBiological AvailabilityEvaluation Studies as TopicFemaleFerritinsHemoglobinsHumansInfantInfant FoodInfant Nutritional Physiological PhenomenaIntestinal AbsorptionIronLongitudinal StudiesSoybeans

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3763274

Citation

Hertrampf, E, et al. "Bioavailability of Iron in Soy-based Formula and Its Effect On Iron Nutriture in Infancy." Pediatrics, vol. 78, no. 4, 1986, pp. 640-5.
Hertrampf E, Cayazzo M, Pizarro F, et al. Bioavailability of iron in soy-based formula and its effect on iron nutriture in infancy. Pediatrics. 1986;78(4):640-5.
Hertrampf, E., Cayazzo, M., Pizarro, F., & Stekel, A. (1986). Bioavailability of iron in soy-based formula and its effect on iron nutriture in infancy. Pediatrics, 78(4), 640-5.
Hertrampf E, et al. Bioavailability of Iron in Soy-based Formula and Its Effect On Iron Nutriture in Infancy. Pediatrics. 1986;78(4):640-5. PubMed PMID: 3763274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of iron in soy-based formula and its effect on iron nutriture in infancy. AU - Hertrampf,E, AU - Cayazzo,M, AU - Pizarro,F, AU - Stekel,A, PY - 1986/10/1/pubmed PY - 1986/10/1/medline PY - 1986/10/1/entrez SP - 640 EP - 5 JF - Pediatrics JO - Pediatrics VL - 78 IS - 4 N2 - Soy products have been reported to inhibit absorption of nonheme food iron and fortification iron. Iron bioavailability from a soy formula (Prosobee-PP 710) (iron added as ferrous sulfate: 12 mg/L; ascorbic acid: 54 mg/L) was examined in 16 adult women using the extrinsic radioactive tag method. The geometric mean absorption from the soy formula was only 1.7%. The effect of this formula on iron nutrition in infants was studied in 47 healthy term infants weaned spontaneously before 2 months of age and who received the formula ad libitum until 9 months of age. For control, 45 infants received a cow's milk formula fortified with ferrous sulfate (iron: 15 mg/L; ascorbic acid: 100 mg/L), which has been shown to be effective in preventing iron deficiency, and 49 additional breast-fed infants were also followed. All babies received solid foods (vegetables and meat) starting at 4 months of age. Iron nutritional status was determined at 9 months. Infants fed soy formula and iron-fortified cow's milk had similar mean values of hemoglobin, mean corpuscular volume, transferrin saturation, free erythrocyte protoporphyrin, and serum ferritin; both formula groups differed significantly (P less than .05) from the breast-fed group in all measurements except free erythrocyte protoporphyrin. Anemia (hemoglobin less than 11 g/dL) was present in only 4.3% and 2.2% of infants receiving the soy and the fortified formulas, respectively, v 27.3% in the breast-fed group. These results indicate that soy formula, in spite of the lower iron bioavailability when measured in adults, is essentially as effective as iron-fortified cow's milk in preventing iron deficiency in infants. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/3763274/Bioavailability_of_iron_in_soy_based_formula_and_its_effect_on_iron_nutriture_in_infancy_ DB - PRIME DP - Unbound Medicine ER -