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Bioavailability of iron in soy-based formula and its effect on iron nutriture in infancy.
Pediatrics. 1986 Oct; 78(4):640-5.Ped

Abstract

Soy products have been reported to inhibit absorption of nonheme food iron and fortification iron. Iron bioavailability from a soy formula (Prosobee-PP 710) (iron added as ferrous sulfate: 12 mg/L; ascorbic acid: 54 mg/L) was examined in 16 adult women using the extrinsic radioactive tag method. The geometric mean absorption from the soy formula was only 1.7%. The effect of this formula on iron nutrition in infants was studied in 47 healthy term infants weaned spontaneously before 2 months of age and who received the formula ad libitum until 9 months of age. For control, 45 infants received a cow's milk formula fortified with ferrous sulfate (iron: 15 mg/L; ascorbic acid: 100 mg/L), which has been shown to be effective in preventing iron deficiency, and 49 additional breast-fed infants were also followed. All babies received solid foods (vegetables and meat) starting at 4 months of age. Iron nutritional status was determined at 9 months. Infants fed soy formula and iron-fortified cow's milk had similar mean values of hemoglobin, mean corpuscular volume, transferrin saturation, free erythrocyte protoporphyrin, and serum ferritin; both formula groups differed significantly (P less than .05) from the breast-fed group in all measurements except free erythrocyte protoporphyrin. Anemia (hemoglobin less than 11 g/dL) was present in only 4.3% and 2.2% of infants receiving the soy and the fortified formulas, respectively, v 27.3% in the breast-fed group. These results indicate that soy formula, in spite of the lower iron bioavailability when measured in adults, is essentially as effective as iron-fortified cow's milk in preventing iron deficiency in infants.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3763274

Citation

Hertrampf, E, et al. "Bioavailability of Iron in Soy-based Formula and Its Effect On Iron Nutriture in Infancy." Pediatrics, vol. 78, no. 4, 1986, pp. 640-5.
Hertrampf E, Cayazzo M, Pizarro F, et al. Bioavailability of iron in soy-based formula and its effect on iron nutriture in infancy. Pediatrics. 1986;78(4):640-5.
Hertrampf, E., Cayazzo, M., Pizarro, F., & Stekel, A. (1986). Bioavailability of iron in soy-based formula and its effect on iron nutriture in infancy. Pediatrics, 78(4), 640-5.
Hertrampf E, et al. Bioavailability of Iron in Soy-based Formula and Its Effect On Iron Nutriture in Infancy. Pediatrics. 1986;78(4):640-5. PubMed PMID: 3763274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of iron in soy-based formula and its effect on iron nutriture in infancy. AU - Hertrampf,E, AU - Cayazzo,M, AU - Pizarro,F, AU - Stekel,A, PY - 1986/10/1/pubmed PY - 1986/10/1/medline PY - 1986/10/1/entrez SP - 640 EP - 5 JF - Pediatrics JO - Pediatrics VL - 78 IS - 4 N2 - Soy products have been reported to inhibit absorption of nonheme food iron and fortification iron. Iron bioavailability from a soy formula (Prosobee-PP 710) (iron added as ferrous sulfate: 12 mg/L; ascorbic acid: 54 mg/L) was examined in 16 adult women using the extrinsic radioactive tag method. The geometric mean absorption from the soy formula was only 1.7%. The effect of this formula on iron nutrition in infants was studied in 47 healthy term infants weaned spontaneously before 2 months of age and who received the formula ad libitum until 9 months of age. For control, 45 infants received a cow's milk formula fortified with ferrous sulfate (iron: 15 mg/L; ascorbic acid: 100 mg/L), which has been shown to be effective in preventing iron deficiency, and 49 additional breast-fed infants were also followed. All babies received solid foods (vegetables and meat) starting at 4 months of age. Iron nutritional status was determined at 9 months. Infants fed soy formula and iron-fortified cow's milk had similar mean values of hemoglobin, mean corpuscular volume, transferrin saturation, free erythrocyte protoporphyrin, and serum ferritin; both formula groups differed significantly (P less than .05) from the breast-fed group in all measurements except free erythrocyte protoporphyrin. Anemia (hemoglobin less than 11 g/dL) was present in only 4.3% and 2.2% of infants receiving the soy and the fortified formulas, respectively, v 27.3% in the breast-fed group. These results indicate that soy formula, in spite of the lower iron bioavailability when measured in adults, is essentially as effective as iron-fortified cow's milk in preventing iron deficiency in infants. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/3763274/Bioavailability_of_iron_in_soy_based_formula_and_its_effect_on_iron_nutriture_in_infancy_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=3763274 DB - PRIME DP - Unbound Medicine ER -