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Histologic criteria for the diagnosis of pityriasis rubra pilaris.
Am J Dermatopathol. 1986 Aug; 8(4):277-83.AJ

Abstract

Even though the clinical appearance of pityriasis rubra pilaris is often distinctive enough to allow specific diagnosis of it, criteria for its histologic diagnosis have not yet been well defined. On the basis of a study of 55 cases of pityriasis rubra pilaris, we found the following histologic features helpful for diagnosis throughout most of the course of the disease: alternating orthokeratosis and parakeratosis in both vertical and horizontal directions; focal or confluent hypergranulosis; thick suprapapillary plates; broad rete ridges; narrow dermal papillae; and sparse superficial perivascular infiltration, mostly of lymphocytes. Plugging of follicular infundibula by cornified cells was seen only in biopsy specimens that came from lesions that were clinically indubitably follicular. Psoriasis has many histologic features in common with pityriasis rubra pilaris, but evolving and fully developed lesions of psoriasis have neutrophils in mounds of parakeratosis, thin rete ridges, thin suprapapillary plates, broad dermal papillae, and mixed inflammatory cell infiltrates of variable density.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3766917

Citation

Soeprono, F F.. "Histologic Criteria for the Diagnosis of Pityriasis Rubra Pilaris." The American Journal of Dermatopathology, vol. 8, no. 4, 1986, pp. 277-83.
Soeprono FF. Histologic criteria for the diagnosis of pityriasis rubra pilaris. Am J Dermatopathol. 1986;8(4):277-83.
Soeprono, F. F. (1986). Histologic criteria for the diagnosis of pityriasis rubra pilaris. The American Journal of Dermatopathology, 8(4), 277-83.
Soeprono FF. Histologic Criteria for the Diagnosis of Pityriasis Rubra Pilaris. Am J Dermatopathol. 1986;8(4):277-83. PubMed PMID: 3766917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histologic criteria for the diagnosis of pityriasis rubra pilaris. A1 - Soeprono,F F, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 277 EP - 83 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 8 IS - 4 N2 - Even though the clinical appearance of pityriasis rubra pilaris is often distinctive enough to allow specific diagnosis of it, criteria for its histologic diagnosis have not yet been well defined. On the basis of a study of 55 cases of pityriasis rubra pilaris, we found the following histologic features helpful for diagnosis throughout most of the course of the disease: alternating orthokeratosis and parakeratosis in both vertical and horizontal directions; focal or confluent hypergranulosis; thick suprapapillary plates; broad rete ridges; narrow dermal papillae; and sparse superficial perivascular infiltration, mostly of lymphocytes. Plugging of follicular infundibula by cornified cells was seen only in biopsy specimens that came from lesions that were clinically indubitably follicular. Psoriasis has many histologic features in common with pityriasis rubra pilaris, but evolving and fully developed lesions of psoriasis have neutrophils in mounds of parakeratosis, thin rete ridges, thin suprapapillary plates, broad dermal papillae, and mixed inflammatory cell infiltrates of variable density. SN - 0193-1091 UR - https://www.unboundmedicine.com/medline/citation/3766917/Histologic_criteria_for_the_diagnosis_of_pityriasis_rubra_pilaris_ DB - PRIME DP - Unbound Medicine ER -