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[Endoscopic obturation of esophagogastric varices with bucrylate. II. Morphologic study based on 12 autopsy cases].
Gastroenterol Clin Biol. 1986 Aug-Sep; 10(8-9):580-3.GC

Abstract

The authors report the results of postmortem histopathological studies in 12 patients who had been treated by endoscopic obliteration of esophagogastric varices with Bucrylate (isobutyl-2-cyanoacrylate). All patients had cirrhosis; 11 patients were Pugh classe C. Eleven patients had esophageal injections. Acute esophageal lesions were characterized by ulcerations in obliterated varices and diffusion of Bucrylate into the esophageal wall. Chronic lesions were characterized by disappearance of varices and Bucrylate, extending fibrosis of the esophageal wall and re-epithelialization of the mucosa. In one patient who had received gastric injections only, non ulcerated Bucrylate filled gastric varices were seen. Bucrylate seems to have a dual action on esophageal varices: immediate obliteration and acute necrosis of the vascular endothelium. Necrosis causes diffusion of Bucrylate through the esophageal wall, and later, secondary fibrosis whereas the product is progressively eliminated into the esophageal lumen.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

3781161

Citation

Fabiani, B, et al. "[Endoscopic Obturation of Esophagogastric Varices With Bucrylate. II. Morphologic Study Based On 12 Autopsy Cases]." Gastroenterologie Clinique Et Biologique, vol. 10, no. 8-9, 1986, pp. 580-3.
Fabiani B, Degott C, Ramond MJ, et al. [Endoscopic obturation of esophagogastric varices with bucrylate. II. Morphologic study based on 12 autopsy cases]. Gastroenterol Clin Biol. 1986;10(8-9):580-3.
Fabiani, B., Degott, C., Ramond, M. J., Valla, D., Benhamou, J. P., & Potet, F. (1986). [Endoscopic obturation of esophagogastric varices with bucrylate. II. Morphologic study based on 12 autopsy cases]. Gastroenterologie Clinique Et Biologique, 10(8-9), 580-3.
Fabiani B, et al. [Endoscopic Obturation of Esophagogastric Varices With Bucrylate. II. Morphologic Study Based On 12 Autopsy Cases]. Gastroenterol Clin Biol. 1986 Aug-Sep;10(8-9):580-3. PubMed PMID: 3781161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Endoscopic obturation of esophagogastric varices with bucrylate. II. Morphologic study based on 12 autopsy cases]. AU - Fabiani,B, AU - Degott,C, AU - Ramond,M J, AU - Valla,D, AU - Benhamou,J P, AU - Potet,F, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 580 EP - 3 JF - Gastroenterologie clinique et biologique JO - Gastroenterol Clin Biol VL - 10 IS - 8-9 N2 - The authors report the results of postmortem histopathological studies in 12 patients who had been treated by endoscopic obliteration of esophagogastric varices with Bucrylate (isobutyl-2-cyanoacrylate). All patients had cirrhosis; 11 patients were Pugh classe C. Eleven patients had esophageal injections. Acute esophageal lesions were characterized by ulcerations in obliterated varices and diffusion of Bucrylate into the esophageal wall. Chronic lesions were characterized by disappearance of varices and Bucrylate, extending fibrosis of the esophageal wall and re-epithelialization of the mucosa. In one patient who had received gastric injections only, non ulcerated Bucrylate filled gastric varices were seen. Bucrylate seems to have a dual action on esophageal varices: immediate obliteration and acute necrosis of the vascular endothelium. Necrosis causes diffusion of Bucrylate through the esophageal wall, and later, secondary fibrosis whereas the product is progressively eliminated into the esophageal lumen. SN - 0399-8320 UR - https://www.unboundmedicine.com/medline/citation/3781161/[Endoscopic_obturation_of_esophagogastric_varices_with_bucrylate__II__Morphologic_study_based_on_12_autopsy_cases]_ DB - PRIME DP - Unbound Medicine ER -