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Immunoglobulin production by coeliac biopsies in organ culture.
Gut. 1986 Oct; 27(10):1151-60.Gut

Abstract

The production of immunoglobulins by jejunal mucosa during organ culture has been studied. In 18 untreated coeliac patients the amounts of IgA, secretory IgA and IgM in the culture medium were higher than in those from 17 normal controls. The results in 15 treated coeliac patients did not differ from the control subjects. Mucosal biopsies from patients with serum IgA deficiency produced very little IgA, but large amounts of IgG and IgM. The addition of neither Frazer's gluten fraction III, nor alpha-gliadin to the culture system stimulated any additional increased secretion of immunoglobulins from the untreated coeliac patients. Production of IgA and IgM by the small bowel mucosa continues during organ culture, but that of IgG appears insignificant.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3781327

Citation

Wood, G M., et al. "Immunoglobulin Production By Coeliac Biopsies in Organ Culture." Gut, vol. 27, no. 10, 1986, pp. 1151-60.
Wood GM, Shires S, Howdle PD, et al. Immunoglobulin production by coeliac biopsies in organ culture. Gut. 1986;27(10):1151-60.
Wood, G. M., Shires, S., Howdle, P. D., & Losowsky, M. S. (1986). Immunoglobulin production by coeliac biopsies in organ culture. Gut, 27(10), 1151-60.
Wood GM, et al. Immunoglobulin Production By Coeliac Biopsies in Organ Culture. Gut. 1986;27(10):1151-60. PubMed PMID: 3781327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin production by coeliac biopsies in organ culture. AU - Wood,G M, AU - Shires,S, AU - Howdle,P D, AU - Losowsky,M S, PY - 1986/10/1/pubmed PY - 1986/10/1/medline PY - 1986/10/1/entrez SP - 1151 EP - 60 JF - Gut JO - Gut VL - 27 IS - 10 N2 - The production of immunoglobulins by jejunal mucosa during organ culture has been studied. In 18 untreated coeliac patients the amounts of IgA, secretory IgA and IgM in the culture medium were higher than in those from 17 normal controls. The results in 15 treated coeliac patients did not differ from the control subjects. Mucosal biopsies from patients with serum IgA deficiency produced very little IgA, but large amounts of IgG and IgM. The addition of neither Frazer's gluten fraction III, nor alpha-gliadin to the culture system stimulated any additional increased secretion of immunoglobulins from the untreated coeliac patients. Production of IgA and IgM by the small bowel mucosa continues during organ culture, but that of IgG appears insignificant. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/3781327/Immunoglobulin_production_by_coeliac_biopsies_in_organ_culture_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&pmid=3781327 DB - PRIME DP - Unbound Medicine ER -