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The IgG subclass distribution of thyroid autoantibodies.
Immunol Lett. 1986 Nov 03; 13(6):335-41.IL

Abstract

There have been several conflicting reports concerning the subclass distribution of thyroid autoantibodies. We have therefore reinvestigated this with both a radioimmunoassay and an ELISA based on the use of a variety of monoclonal antibodies. Our results demonstrate the presence of subclasses IgG1, IgG2, IgG3 and IgG4 in both thyroglobulin and microsomal autoantibodies from patients with either Graves' disease or Hashimoto's thyroiditis. However, in many patients there is over-representation of the IgG4 subclass. We also found marked differences in the binding characteristics of monoclonal antibodies directed against the same subclasses, underlining the need for appropriate selection of such monoclonal reagents in any assay.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3781568

Citation

Weetman, A P., and S Cohen. "The IgG Subclass Distribution of Thyroid Autoantibodies." Immunology Letters, vol. 13, no. 6, 1986, pp. 335-41.
Weetman AP, Cohen S. The IgG subclass distribution of thyroid autoantibodies. Immunol Lett. 1986;13(6):335-41.
Weetman, A. P., & Cohen, S. (1986). The IgG subclass distribution of thyroid autoantibodies. Immunology Letters, 13(6), 335-41.
Weetman AP, Cohen S. The IgG Subclass Distribution of Thyroid Autoantibodies. Immunol Lett. 1986 Nov 3;13(6):335-41. PubMed PMID: 3781568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The IgG subclass distribution of thyroid autoantibodies. AU - Weetman,A P, AU - Cohen,S, PY - 1986/11/3/pubmed PY - 1986/11/3/medline PY - 1986/11/3/entrez SP - 335 EP - 41 JF - Immunology letters JO - Immunol. Lett. VL - 13 IS - 6 N2 - There have been several conflicting reports concerning the subclass distribution of thyroid autoantibodies. We have therefore reinvestigated this with both a radioimmunoassay and an ELISA based on the use of a variety of monoclonal antibodies. Our results demonstrate the presence of subclasses IgG1, IgG2, IgG3 and IgG4 in both thyroglobulin and microsomal autoantibodies from patients with either Graves' disease or Hashimoto's thyroiditis. However, in many patients there is over-representation of the IgG4 subclass. We also found marked differences in the binding characteristics of monoclonal antibodies directed against the same subclasses, underlining the need for appropriate selection of such monoclonal reagents in any assay. SN - 0165-2478 UR - https://www.unboundmedicine.com/medline/citation/3781568/The_IgG_subclass_distribution_of_thyroid_autoantibodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0165-2478(86)90068-4 DB - PRIME DP - Unbound Medicine ER -