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Red wine asthma: a controlled challenge study.

Abstract

Drinking red wine may provoke bronchospasm in subjects with asthma. In order to reveal some of the possible agents involved in this reaction, 18 patients with a history of red wine-induced asthma were studied. They received, in a double-blind fashion, red wine with low sulfur dioxide (SO2) and high amine, high SO2 and high amine and low SO2 and low amine content. In each challenge, the wine was administered in stepwise increasing quantities until a total of 385 ml or a fall in peak expiratory flow of greater than 15% was reached. Nine subjects demonstrated a significant fall in peak flow in one or more challenges. In all cases the most severe reaction was observed after the wine with high SO2 content. The study suggests that SO2 is the most important factor in red wine-induced asthma. It is recommended that wine labels provide information on the SO2 content.

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    MeSH

    Adult
    Asthma
    Biogenic Amines
    Double-Blind Method
    Female
    Food Hypersensitivity
    Humans
    Male
    Middle Aged
    Random Allocation
    Respiratory Function Tests
    Sulfur Dioxide
    Wine

    Pub Type(s)

    Clinical Trial
    Controlled Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    3782677

    Citation

    Dahl, R, et al. "Red Wine Asthma: a Controlled Challenge Study." The Journal of Allergy and Clinical Immunology, vol. 78, no. 6, 1986, pp. 1126-9.
    Dahl R, Henriksen JM, Harving H. Red wine asthma: a controlled challenge study. J Allergy Clin Immunol. 1986;78(6):1126-9.
    Dahl, R., Henriksen, J. M., & Harving, H. (1986). Red wine asthma: a controlled challenge study. The Journal of Allergy and Clinical Immunology, 78(6), pp. 1126-9.
    Dahl R, Henriksen JM, Harving H. Red Wine Asthma: a Controlled Challenge Study. J Allergy Clin Immunol. 1986;78(6):1126-9. PubMed PMID: 3782677.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Red wine asthma: a controlled challenge study. AU - Dahl,R, AU - Henriksen,J M, AU - Harving,H, PY - 1986/12/1/pubmed PY - 1986/12/1/medline PY - 1986/12/1/entrez SP - 1126 EP - 9 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 78 IS - 6 N2 - Drinking red wine may provoke bronchospasm in subjects with asthma. In order to reveal some of the possible agents involved in this reaction, 18 patients with a history of red wine-induced asthma were studied. They received, in a double-blind fashion, red wine with low sulfur dioxide (SO2) and high amine, high SO2 and high amine and low SO2 and low amine content. In each challenge, the wine was administered in stepwise increasing quantities until a total of 385 ml or a fall in peak expiratory flow of greater than 15% was reached. Nine subjects demonstrated a significant fall in peak flow in one or more challenges. In all cases the most severe reaction was observed after the wine with high SO2 content. The study suggests that SO2 is the most important factor in red wine-induced asthma. It is recommended that wine labels provide information on the SO2 content. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/3782677/Red_wine_asthma:_a_controlled_challenge_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-6749(86)90261-7 DB - PRIME DP - Unbound Medicine ER -