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Experimental retraction pocket cholesteatoma.
Ann Otol Rhinol Laryngol. 1986 Nov-Dec; 95(6 Pt 1):639-44.AO

Abstract

An animal model for retraction pocket (primary acquired) cholesteatoma is presented. Bilateral eustachian tube obstruction by electrocauterization of the nasopharyngeal portion was performed in 16 Mongolian gerbils. Animals were killed at 2, 4, 8, and 16 weeks. At 2 weeks all animals had bilateral serous effusions and retracted tympanic membranes. At 4 weeks, four of eight ears had middle ear fluid, retractions, and cholesteatomas. After 8 weeks, five of eight ears had middle ear effusions, and four of these had cholesteatomas; one ear had total atelectasis with a cholesteatoma filling the bulla. By 16 weeks, six of eight ears had developed cholesteatomas. Some animals did not develop effusion or retraction because of failure or recanalization of eustachian tube obstruction. This study provides experimental evidence that aural cholesteatomas may arise by retraction of the tympanic membrane.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3789599

Citation

Wolfman, D E., and R A. Chole. "Experimental Retraction Pocket Cholesteatoma." The Annals of Otology, Rhinology, and Laryngology, vol. 95, no. 6 Pt 1, 1986, pp. 639-44.
Wolfman DE, Chole RA. Experimental retraction pocket cholesteatoma. Ann Otol Rhinol Laryngol. 1986;95(6 Pt 1):639-44.
Wolfman, D. E., & Chole, R. A. (1986). Experimental retraction pocket cholesteatoma. The Annals of Otology, Rhinology, and Laryngology, 95(6 Pt 1), 639-44.
Wolfman DE, Chole RA. Experimental Retraction Pocket Cholesteatoma. Ann Otol Rhinol Laryngol. 1986 Nov-Dec;95(6 Pt 1):639-44. PubMed PMID: 3789599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental retraction pocket cholesteatoma. AU - Wolfman,D E, AU - Chole,R A, PY - 1986/11/1/pubmed PY - 1986/11/1/medline PY - 1986/11/1/entrez SP - 639 EP - 44 JF - The Annals of otology, rhinology, and laryngology JO - Ann Otol Rhinol Laryngol VL - 95 IS - 6 Pt 1 N2 - An animal model for retraction pocket (primary acquired) cholesteatoma is presented. Bilateral eustachian tube obstruction by electrocauterization of the nasopharyngeal portion was performed in 16 Mongolian gerbils. Animals were killed at 2, 4, 8, and 16 weeks. At 2 weeks all animals had bilateral serous effusions and retracted tympanic membranes. At 4 weeks, four of eight ears had middle ear fluid, retractions, and cholesteatomas. After 8 weeks, five of eight ears had middle ear effusions, and four of these had cholesteatomas; one ear had total atelectasis with a cholesteatoma filling the bulla. By 16 weeks, six of eight ears had developed cholesteatomas. Some animals did not develop effusion or retraction because of failure or recanalization of eustachian tube obstruction. This study provides experimental evidence that aural cholesteatomas may arise by retraction of the tympanic membrane. SN - 0003-4894 UR - https://www.unboundmedicine.com/medline/citation/3789599/Experimental_retraction_pocket_cholesteatoma_ DB - PRIME DP - Unbound Medicine ER -