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Immunoglobulin G subclasses of anti-thyroid peroxidase autoantibodies in human autoimmune thyroid diseases.
Endocrinol Jpn 1986; 33(4):505-10EJ

Abstract

A distribution of immunoglobulin G (IgG) subclass of anti-thyroid peroxidase (TPO) autoantibodies was studied to know whether anti-TPO autoantibodies are closely implicated in the pathogenesis of human autoimmune thyroid diseases. As a result of analyzing 14 patients' sera, 7 with Graves' disease and 7 with Hashimoto's thyroiditis, anti-TPO autoantibodies were found to consist of mainly IgG1 subclass. Percentages of both IgG1 and IgG2 subclasses in IgG class of autoantibodies corresponded to those in the normal serum composition, whereas IgG3 subclass was scarcely contained in anti-TPO autoantibodies and IgG4 subclass markedly increased. It was thought that anti-TPO autoantibodies had a capability to lyse thyroid follicular cells by the mechanism of antibody-dependent complement-mediated cytolysis, because IgG1 and IgG2 subclasses of antibodies can fix complement and TPO locates in apical membrane surface of thyroid follicular cells. Comparing Graves' disease with Hashimoto's thyroiditis, mean percentages of both IgG1 and IgG2 subclasses of 2 groups were statistically different. Namely, sera of patients with Graves' disease had higher and lower mean percentages of IgG1 and IgG2 subclasses of autoantibodies, respectively, than those with Hashimoto's thyroiditis, though no plausible explanation for these differences can be offered at the present time.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3792276

Citation

Kotani, T, et al. "Immunoglobulin G Subclasses of Anti-thyroid Peroxidase Autoantibodies in Human Autoimmune Thyroid Diseases." Endocrinologia Japonica, vol. 33, no. 4, 1986, pp. 505-10.
Kotani T, Kato E, Hirai K, et al. Immunoglobulin G subclasses of anti-thyroid peroxidase autoantibodies in human autoimmune thyroid diseases. Endocrinol Jpn. 1986;33(4):505-10.
Kotani, T., Kato, E., Hirai, K., Kuma, K., & Ohtaki, S. (1986). Immunoglobulin G subclasses of anti-thyroid peroxidase autoantibodies in human autoimmune thyroid diseases. Endocrinologia Japonica, 33(4), pp. 505-10.
Kotani T, et al. Immunoglobulin G Subclasses of Anti-thyroid Peroxidase Autoantibodies in Human Autoimmune Thyroid Diseases. Endocrinol Jpn. 1986;33(4):505-10. PubMed PMID: 3792276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin G subclasses of anti-thyroid peroxidase autoantibodies in human autoimmune thyroid diseases. AU - Kotani,T, AU - Kato,E, AU - Hirai,K, AU - Kuma,K, AU - Ohtaki,S, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 505 EP - 10 JF - Endocrinologia japonica JO - Endocrinol. Jpn. VL - 33 IS - 4 N2 - A distribution of immunoglobulin G (IgG) subclass of anti-thyroid peroxidase (TPO) autoantibodies was studied to know whether anti-TPO autoantibodies are closely implicated in the pathogenesis of human autoimmune thyroid diseases. As a result of analyzing 14 patients' sera, 7 with Graves' disease and 7 with Hashimoto's thyroiditis, anti-TPO autoantibodies were found to consist of mainly IgG1 subclass. Percentages of both IgG1 and IgG2 subclasses in IgG class of autoantibodies corresponded to those in the normal serum composition, whereas IgG3 subclass was scarcely contained in anti-TPO autoantibodies and IgG4 subclass markedly increased. It was thought that anti-TPO autoantibodies had a capability to lyse thyroid follicular cells by the mechanism of antibody-dependent complement-mediated cytolysis, because IgG1 and IgG2 subclasses of antibodies can fix complement and TPO locates in apical membrane surface of thyroid follicular cells. Comparing Graves' disease with Hashimoto's thyroiditis, mean percentages of both IgG1 and IgG2 subclasses of 2 groups were statistically different. Namely, sera of patients with Graves' disease had higher and lower mean percentages of IgG1 and IgG2 subclasses of autoantibodies, respectively, than those with Hashimoto's thyroiditis, though no plausible explanation for these differences can be offered at the present time. SN - 0013-7219 UR - https://www.unboundmedicine.com/medline/citation/3792276/Immunoglobulin_G_subclasses_of_anti_thyroid_peroxidase_autoantibodies_in_human_autoimmune_thyroid_diseases_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/endocrj1954/33.505?from=PubMed DB - PRIME DP - Unbound Medicine ER -