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Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion.
Digestion. 1986; 35 Suppl 1:42-55.D

Abstract

Small intramucosal tumours in the oxyntic area of the rat stomach were observed in an oncogenicity study with omeprazole. The tumours could be defined as carcinoids of enterochromaffin-like (ECL) cell origin. ECL cells occur exclusively in oxyntic mucosa and respond to the trophic hormone gastrin with a proliferation that becomes exaggerated in old rats. Inhibition of gastric acid secretion is known to induce hypergastrinaemia in rats. According to the common concept of endocrine cells, a sustained hormonal stimulation with gastrin may induce a continuous gradient between hyperplasia and neoplasia of the ECL cells. The tumours found are thus to be regarded as hormone-induced endocrine tumours of the ECL cells in the stomach. The ECL-cell tumours of the rats in the oncogenicity study appeared to belong to the low-malignancy type of carcinoids and did not make their appearance until the end-life period of the study. The sex and species differences observed may be explained by inherent differences in gastrin response, spontaneous ECL cell density or in responsiveness to gastrin-stimulated ECL cell proliferation between sexes and species.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3792671

Citation

Havu, N. "Enterochromaffin-like Cell Carcinoids of Gastric Mucosa in Rats After Life-long Inhibition of Gastric Secretion." Digestion, vol. 35 Suppl 1, 1986, pp. 42-55.
Havu N. Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion. Digestion. 1986;35 Suppl 1:42-55.
Havu, N. (1986). Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion. Digestion, 35 Suppl 1, 42-55.
Havu N. Enterochromaffin-like Cell Carcinoids of Gastric Mucosa in Rats After Life-long Inhibition of Gastric Secretion. Digestion. 1986;35 Suppl 1:42-55. PubMed PMID: 3792671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion. A1 - Havu,N, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 42 EP - 55 JF - Digestion JO - Digestion VL - 35 Suppl 1 N2 - Small intramucosal tumours in the oxyntic area of the rat stomach were observed in an oncogenicity study with omeprazole. The tumours could be defined as carcinoids of enterochromaffin-like (ECL) cell origin. ECL cells occur exclusively in oxyntic mucosa and respond to the trophic hormone gastrin with a proliferation that becomes exaggerated in old rats. Inhibition of gastric acid secretion is known to induce hypergastrinaemia in rats. According to the common concept of endocrine cells, a sustained hormonal stimulation with gastrin may induce a continuous gradient between hyperplasia and neoplasia of the ECL cells. The tumours found are thus to be regarded as hormone-induced endocrine tumours of the ECL cells in the stomach. The ECL-cell tumours of the rats in the oncogenicity study appeared to belong to the low-malignancy type of carcinoids and did not make their appearance until the end-life period of the study. The sex and species differences observed may be explained by inherent differences in gastrin response, spontaneous ECL cell density or in responsiveness to gastrin-stimulated ECL cell proliferation between sexes and species. SN - 0012-2823 UR - https://www.unboundmedicine.com/medline/citation/3792671/Enterochromaffin_like_cell_carcinoids_of_gastric_mucosa_in_rats_after_life_long_inhibition_of_gastric_secretion_ L2 - https://www.karger.com?DOI=10.1159/000199381 DB - PRIME DP - Unbound Medicine ER -