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The influence of dietary manipulation with n-3 and n-6 fatty acids on liver and plasma phospholipid fatty acids in rats.
Lipids 1986; 21(10):652-6L

Abstract

The interrelations between linoleic acid (LA) metabolites and fish oil fatty acids were studied. Sprague-Dawley rats (200-220 g) were fed a fat-free semisynthetic diet supplemented with 10% (by weight) of different combinations of evening primrose oil (EPO), a rich source of LA and gamma-linolenic acid, and polepa (POL), a marine oil rich in eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. The combinations of supplement were as follows: 9% EPO-1% POL, 8% EPO-2% POL, 7% EPO-3% POL, 6% EPO-4% POL and 5% EPO-5% POL. After two weeks on the respective diets, the animals were killed, and the fatty acid compositions of liver and plasma phospholipids were examined. The results showed that animals fed higher proportions of POL consistently contained higher levels of dihomo-gamma-linolenic acid (DGLA) (p less than 0.05), a metabolite of LA and GLA, and lower levels of arachidonic acid (AA) (p less than 0.01), a metabolite of DGLA through delta-5-desaturation. Thus, an inverse relationship between AA/DGLA ratio and EPA levels was found to exist (r = -0.765 in plasma and -0.792 in liver). However, there was no such relationship between AA/DGLA ratio and DHA levels. This result suggested that EPA but not DHA in fish oil exerts an inhibitory effect on the conversion of DGLA to AA.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3796229

Citation

Nassar, B A., et al. "The Influence of Dietary Manipulation With N-3 and N-6 Fatty Acids On Liver and Plasma Phospholipid Fatty Acids in Rats." Lipids, vol. 21, no. 10, 1986, pp. 652-6.
Nassar BA, Huang YS, Manku MS, et al. The influence of dietary manipulation with n-3 and n-6 fatty acids on liver and plasma phospholipid fatty acids in rats. Lipids. 1986;21(10):652-6.
Nassar, B. A., Huang, Y. S., Manku, M. S., Das, U. N., Morse, N., & Horrobin, D. F. (1986). The influence of dietary manipulation with n-3 and n-6 fatty acids on liver and plasma phospholipid fatty acids in rats. Lipids, 21(10), pp. 652-6.
Nassar BA, et al. The Influence of Dietary Manipulation With N-3 and N-6 Fatty Acids On Liver and Plasma Phospholipid Fatty Acids in Rats. Lipids. 1986;21(10):652-6. PubMed PMID: 3796229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of dietary manipulation with n-3 and n-6 fatty acids on liver and plasma phospholipid fatty acids in rats. AU - Nassar,B A, AU - Huang,Y S, AU - Manku,M S, AU - Das,U N, AU - Morse,N, AU - Horrobin,D F, PY - 1986/10/1/pubmed PY - 1986/10/1/medline PY - 1986/10/1/entrez SP - 652 EP - 6 JF - Lipids JO - Lipids VL - 21 IS - 10 N2 - The interrelations between linoleic acid (LA) metabolites and fish oil fatty acids were studied. Sprague-Dawley rats (200-220 g) were fed a fat-free semisynthetic diet supplemented with 10% (by weight) of different combinations of evening primrose oil (EPO), a rich source of LA and gamma-linolenic acid, and polepa (POL), a marine oil rich in eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. The combinations of supplement were as follows: 9% EPO-1% POL, 8% EPO-2% POL, 7% EPO-3% POL, 6% EPO-4% POL and 5% EPO-5% POL. After two weeks on the respective diets, the animals were killed, and the fatty acid compositions of liver and plasma phospholipids were examined. The results showed that animals fed higher proportions of POL consistently contained higher levels of dihomo-gamma-linolenic acid (DGLA) (p less than 0.05), a metabolite of LA and GLA, and lower levels of arachidonic acid (AA) (p less than 0.01), a metabolite of DGLA through delta-5-desaturation. Thus, an inverse relationship between AA/DGLA ratio and EPA levels was found to exist (r = -0.765 in plasma and -0.792 in liver). However, there was no such relationship between AA/DGLA ratio and DHA levels. This result suggested that EPA but not DHA in fish oil exerts an inhibitory effect on the conversion of DGLA to AA. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/3796229/The_influence_of_dietary_manipulation_with_n_3_and_n_6_fatty_acids_on_liver_and_plasma_phospholipid_fatty_acids_in_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=1986&volume=21&issue=10&spage=652 DB - PRIME DP - Unbound Medicine ER -