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Antireflux treatment for asthma. Improvement in patients with associated gastroesophageal reflux.
Arch Intern Med 1987; 147(1):56-60AI

Abstract

Fifteen patients with both nonallergic asthma and symptomatic gastroesophageal reflux were studied before and after an eight-week period of vigorous antireflux therapy, which included ranitidine hydrochloride, 150 mg twice a day. Pulmonary and esophageal symptoms were recorded on daily diary cards. Therapy was associated with prompt amelioration of reflux symptoms and with a less dramatic and more delayed improvement in pulmonary symptoms. Objectively, esophageal erosions healed completely in eight of the ten patients who had them at the beginning of the trial, and pulmonary function measurements improved significantly. Intraesophageal infusions of physiologic saline and 0.1N hydrochloric acid in patients and healthy controls did not significantly alter pulmonary function, as measured by standard spirometry. There is a subset of patients in whom bronchoconstriction is triggered by gastroesophageal reflux. Treatment of reflux in such patients may improve their asthma.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3800530

Citation

Harper, P C., et al. "Antireflux Treatment for Asthma. Improvement in Patients With Associated Gastroesophageal Reflux." Archives of Internal Medicine, vol. 147, no. 1, 1987, pp. 56-60.
Harper PC, Bergner A, Kaye MD. Antireflux treatment for asthma. Improvement in patients with associated gastroesophageal reflux. Arch Intern Med. 1987;147(1):56-60.
Harper, P. C., Bergner, A., & Kaye, M. D. (1987). Antireflux treatment for asthma. Improvement in patients with associated gastroesophageal reflux. Archives of Internal Medicine, 147(1), pp. 56-60.
Harper PC, Bergner A, Kaye MD. Antireflux Treatment for Asthma. Improvement in Patients With Associated Gastroesophageal Reflux. Arch Intern Med. 1987;147(1):56-60. PubMed PMID: 3800530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antireflux treatment for asthma. Improvement in patients with associated gastroesophageal reflux. AU - Harper,P C, AU - Bergner,A, AU - Kaye,M D, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 56 EP - 60 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 147 IS - 1 N2 - Fifteen patients with both nonallergic asthma and symptomatic gastroesophageal reflux were studied before and after an eight-week period of vigorous antireflux therapy, which included ranitidine hydrochloride, 150 mg twice a day. Pulmonary and esophageal symptoms were recorded on daily diary cards. Therapy was associated with prompt amelioration of reflux symptoms and with a less dramatic and more delayed improvement in pulmonary symptoms. Objectively, esophageal erosions healed completely in eight of the ten patients who had them at the beginning of the trial, and pulmonary function measurements improved significantly. Intraesophageal infusions of physiologic saline and 0.1N hydrochloric acid in patients and healthy controls did not significantly alter pulmonary function, as measured by standard spirometry. There is a subset of patients in whom bronchoconstriction is triggered by gastroesophageal reflux. Treatment of reflux in such patients may improve their asthma. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/3800530/Antireflux_treatment_for_asthma__Improvement_in_patients_with_associated_gastroesophageal_reflux_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/147/pg/56 DB - PRIME DP - Unbound Medicine ER -