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Experience with multidrug therapy in paucibacillary leprosy.
Indian J Lepr. 1986 Apr-Jun; 58(2):244-50.IJ

Abstract

Eighty paucibacillary leprosy cases were randomly put on two different multidrug regimens for 6 months followed by dapsone monotherapy. Regimen I was according to WHO (1982) recommendations consisting of Dapsone and six once a month rifampicin. In regimen II in addition to above two constituents, clofazimine was added 100 mg on alternate days. Dapsone thereafter was continued in both the regimens upto one year. The efficacy, acceptability and side effects of multidrug regimens were observed for a period of one year. Histopathological assessment was done on completion of multidrug therapy in all cases. A comparative evaluation of effect of two multidrug regimens in paucibacillary leprosy patients is reported. Addition of clofazimine over WHO (1982) recommended regimen appears to have no added benefit. The duration of WHO (1982) recommended regimens was found to be inadequate in many cases.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3805797

Citation

Bhate, R D., et al. "Experience With Multidrug Therapy in Paucibacillary Leprosy." Indian Journal of Leprosy, vol. 58, no. 2, 1986, pp. 244-50.
Bhate RD, Gupta CM, Chattopadhyay SP, et al. Experience with multidrug therapy in paucibacillary leprosy. Indian J Lepr. 1986;58(2):244-50.
Bhate, R. D., Gupta, C. M., Chattopadhyay, S. P., & Singh, I. P. (1986). Experience with multidrug therapy in paucibacillary leprosy. Indian Journal of Leprosy, 58(2), 244-50.
Bhate RD, et al. Experience With Multidrug Therapy in Paucibacillary Leprosy. Indian J Lepr. 1986 Apr-Jun;58(2):244-50. PubMed PMID: 3805797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experience with multidrug therapy in paucibacillary leprosy. AU - Bhate,R D, AU - Gupta,C M, AU - Chattopadhyay,S P, AU - Singh,I P, PY - 1986/4/1/pubmed PY - 1986/4/1/medline PY - 1986/4/1/entrez SP - 244 EP - 50 JF - Indian journal of leprosy JO - Indian J Lepr VL - 58 IS - 2 N2 - Eighty paucibacillary leprosy cases were randomly put on two different multidrug regimens for 6 months followed by dapsone monotherapy. Regimen I was according to WHO (1982) recommendations consisting of Dapsone and six once a month rifampicin. In regimen II in addition to above two constituents, clofazimine was added 100 mg on alternate days. Dapsone thereafter was continued in both the regimens upto one year. The efficacy, acceptability and side effects of multidrug regimens were observed for a period of one year. Histopathological assessment was done on completion of multidrug therapy in all cases. A comparative evaluation of effect of two multidrug regimens in paucibacillary leprosy patients is reported. Addition of clofazimine over WHO (1982) recommended regimen appears to have no added benefit. The duration of WHO (1982) recommended regimens was found to be inadequate in many cases. SN - 0254-9395 UR - https://www.unboundmedicine.com/medline/citation/3805797/Experience_with_multidrug_therapy_in_paucibacillary_leprosy_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -