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[Antioxidative enzyme activity and metabolism of peroxide compounds in the crystalline lens during cataractogenesis].
Biull Eksp Biol Med. 1987 Feb; 103(2):143-6.BE

Abstract

Lens antioxidative enzyme activity (catalase, superoxide dismutase, glutathione peroxidase) in cataract as well as the possibility of cataract induction by the lipid peroxidation products and their influence on the content of reduced thiols (oxy-red balance) were studied. It was shown that the rate of the H2O2 decomposition by the human cataract lenses is lowered in comparison with the normal lenses. This is not due to the lowered catalase or glutathione-peroxidase 1 activity, but depends on the deficiency of reduced glutathione in the lens. Activity of superoxide dismutase and glutathione peroxidase metabolizing organic hydroperoxides is significantly lowered in the cataract lenses. Lipid peroxidation products injected into the rabbit vitreous induce posterior subcapsular cataract, which is accompanied by depletion of reduced glutathione level in the lens. The conclusion is made that two interrelated processes: accumulation of H2O2 and of lipid peroxides induce aggregation of the soluble proteins and the fragmentation of the membrane structures in cataract lenses.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

3814788

Citation

Babizhaev, M a., et al. "[Antioxidative Enzyme Activity and Metabolism of Peroxide Compounds in the Crystalline Lens During Cataractogenesis]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 103, no. 2, 1987, pp. 143-6.
Babizhaev Ma, Arkhipenko IuV, Kagan VE. [Antioxidative enzyme activity and metabolism of peroxide compounds in the crystalline lens during cataractogenesis]. Biull Eksp Biol Med. 1987;103(2):143-6.
Babizhaev, M. a., Arkhipenko, I. u. V., & Kagan, V. E. (1987). [Antioxidative enzyme activity and metabolism of peroxide compounds in the crystalline lens during cataractogenesis]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 103(2), 143-6.
Babizhaev Ma, Arkhipenko IuV, Kagan VE. [Antioxidative Enzyme Activity and Metabolism of Peroxide Compounds in the Crystalline Lens During Cataractogenesis]. Biull Eksp Biol Med. 1987;103(2):143-6. PubMed PMID: 3814788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antioxidative enzyme activity and metabolism of peroxide compounds in the crystalline lens during cataractogenesis]. AU - Babizhaev,M a, AU - Arkhipenko,Iu V, AU - Kagan,V E, PY - 1987/2/1/pubmed PY - 1987/2/1/medline PY - 1987/2/1/entrez SP - 143 EP - 6 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 103 IS - 2 N2 - Lens antioxidative enzyme activity (catalase, superoxide dismutase, glutathione peroxidase) in cataract as well as the possibility of cataract induction by the lipid peroxidation products and their influence on the content of reduced thiols (oxy-red balance) were studied. It was shown that the rate of the H2O2 decomposition by the human cataract lenses is lowered in comparison with the normal lenses. This is not due to the lowered catalase or glutathione-peroxidase 1 activity, but depends on the deficiency of reduced glutathione in the lens. Activity of superoxide dismutase and glutathione peroxidase metabolizing organic hydroperoxides is significantly lowered in the cataract lenses. Lipid peroxidation products injected into the rabbit vitreous induce posterior subcapsular cataract, which is accompanied by depletion of reduced glutathione level in the lens. The conclusion is made that two interrelated processes: accumulation of H2O2 and of lipid peroxides induce aggregation of the soluble proteins and the fragmentation of the membrane structures in cataract lenses. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/3814788/[Antioxidative_enzyme_activity_and_metabolism_of_peroxide_compounds_in_the_crystalline_lens_during_cataractogenesis]_ L2 - https://medlineplus.gov/cataract.html DB - PRIME DP - Unbound Medicine ER -