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Serum immunoglobulins, complements and circulating immune complexes in oral lichen planus.

Abstract

Serum IgG, IgM, IgA, C3, C4 concentrations and circulating immune complexes (CIC) were measured in a series of 46 patients with oral lichen planus (LP). This investigation revealed a significant increase in the level of serum IgG in patients with oral LP as compared with 36 healthy subjects. In erosive LP, serum IgM was also elevated as compared with healthy subjects and patients with the non-erosive type. The results of this study did not support the suggestion that a humoral immunodeficiency underlies oral LP. Elevated serum level of IgM may be considered to represent secondary oral infection during mucosal erosion. The study also demonstrated a significant reduction in serum C4 in both variants of oral LP, but the C3 level was normal. A 3% polyethylene glycol precipitation (PEG-ppt) method was used, no significant amount of CIC could be detected in the patients. It is tempting to speculate that oral LP reflects an immunologic disorder in which serum IgG and C4 is disturbed. However, further investigation is needed to clarify the pathogenesis of oral LP.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3816355

Citation

Sun, A, et al. "Serum Immunoglobulins, Complements and Circulating Immune Complexes in Oral Lichen Planus." Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi = Chinese Journal of Microbiology and Immunology, vol. 19, no. 1, 1986, pp. 46-51.
Sun A, Wu YC, Liang LC, et al. Serum immunoglobulins, complements and circulating immune complexes in oral lichen planus. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1986;19(1):46-51.
Sun, A., Wu, Y. C., Liang, L. C., & Kwan, H. W. (1986). Serum immunoglobulins, complements and circulating immune complexes in oral lichen planus. Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi = Chinese Journal of Microbiology and Immunology, 19(1), 46-51.
Sun A, et al. Serum Immunoglobulins, Complements and Circulating Immune Complexes in Oral Lichen Planus. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1986;19(1):46-51. PubMed PMID: 3816355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum immunoglobulins, complements and circulating immune complexes in oral lichen planus. AU - Sun,A, AU - Wu,Y C, AU - Liang,L C, AU - Kwan,H W, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 46 EP - 51 JF - Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology JO - Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi VL - 19 IS - 1 N2 - Serum IgG, IgM, IgA, C3, C4 concentrations and circulating immune complexes (CIC) were measured in a series of 46 patients with oral lichen planus (LP). This investigation revealed a significant increase in the level of serum IgG in patients with oral LP as compared with 36 healthy subjects. In erosive LP, serum IgM was also elevated as compared with healthy subjects and patients with the non-erosive type. The results of this study did not support the suggestion that a humoral immunodeficiency underlies oral LP. Elevated serum level of IgM may be considered to represent secondary oral infection during mucosal erosion. The study also demonstrated a significant reduction in serum C4 in both variants of oral LP, but the C3 level was normal. A 3% polyethylene glycol precipitation (PEG-ppt) method was used, no significant amount of CIC could be detected in the patients. It is tempting to speculate that oral LP reflects an immunologic disorder in which serum IgG and C4 is disturbed. However, further investigation is needed to clarify the pathogenesis of oral LP. SN - 0253-2662 UR - https://www.unboundmedicine.com/medline/citation/3816355/Serum_immunoglobulins_complements_and_circulating_immune_complexes_in_oral_lichen_planus_ L2 - http://www.diseaseinfosearch.org/result/5399 DB - PRIME DP - Unbound Medicine ER -