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Mechanistic aspects of ingested chlorine dioxide on thyroid function: impact of oxidants on iodide metabolism.
Environ Health Perspect. 1986 Nov; 69:249-54.EH

Abstract

Toxicological studies dealing with recent findings of health effects of drinking water disinfectants are reviewed. Experiments with monkeys and rodents indicate that the biological activity of ingested disinfectants is expressed via their chemical interaction with the mucosal epithelia, secretory products, and nutritional contents of the alimentary tract. Evidence exists that a principal partner of this redox interaction is the iodide of nutritional origin that is ubiquitous in the gastrointestinal tract. Thus the observation that subchronic exposure to chlorine dioxide (ClO2) in drinking water decreases serum thyroxine levels in mammalian species can be best explained with changes produced in the chemical form of the bioavailable iodide. Ongoing and previously reported mechanistic studies indicate that oxidizing agents such as chlorine-based disinfectants oxidize the basal iodide content of the gastrointestinal tract. The resulting reactive iodine species readily attaches to organic matter by covalent bonding. Evidence suggests that the extent to which such iodinated organics are formed is proportional to the magnitude of the electromotive force and stoichiometry of the redox couple between iodide and the disinfectant. Because the extent of thyroid uptake of the bioavailable iodide does not decrease during ClO2 ingestion, it seems that ClO2 does not cause iodide deficiency of sufficient magnitude to account for the decrease in hormonogenesis. Absorption of one or more of iodinated molecules, e.g., nutrients, hormones, or cellular constituents of the alimentary tract having thyromimetic or thyroid inhibitory properties, is a better hypothesis for the effects seen.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3816729

Citation

Bercz, J P., et al. "Mechanistic Aspects of Ingested Chlorine Dioxide On Thyroid Function: Impact of Oxidants On Iodide Metabolism." Environmental Health Perspectives, vol. 69, 1986, pp. 249-54.
Bercz JP, Jones LL, Harrington RM, et al. Mechanistic aspects of ingested chlorine dioxide on thyroid function: impact of oxidants on iodide metabolism. Environ Health Perspect. 1986;69:249-54.
Bercz, J. P., Jones, L. L., Harrington, R. M., Bawa, R., & Condie, L. (1986). Mechanistic aspects of ingested chlorine dioxide on thyroid function: impact of oxidants on iodide metabolism. Environmental Health Perspectives, 69, 249-54.
Bercz JP, et al. Mechanistic Aspects of Ingested Chlorine Dioxide On Thyroid Function: Impact of Oxidants On Iodide Metabolism. Environ Health Perspect. 1986;69:249-54. PubMed PMID: 3816729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanistic aspects of ingested chlorine dioxide on thyroid function: impact of oxidants on iodide metabolism. AU - Bercz,J P, AU - Jones,L L, AU - Harrington,R M, AU - Bawa,R, AU - Condie,L, PY - 1986/11/1/pubmed PY - 1986/11/1/medline PY - 1986/11/1/entrez SP - 249 EP - 54 JF - Environmental health perspectives JO - Environ Health Perspect VL - 69 N2 - Toxicological studies dealing with recent findings of health effects of drinking water disinfectants are reviewed. Experiments with monkeys and rodents indicate that the biological activity of ingested disinfectants is expressed via their chemical interaction with the mucosal epithelia, secretory products, and nutritional contents of the alimentary tract. Evidence exists that a principal partner of this redox interaction is the iodide of nutritional origin that is ubiquitous in the gastrointestinal tract. Thus the observation that subchronic exposure to chlorine dioxide (ClO2) in drinking water decreases serum thyroxine levels in mammalian species can be best explained with changes produced in the chemical form of the bioavailable iodide. Ongoing and previously reported mechanistic studies indicate that oxidizing agents such as chlorine-based disinfectants oxidize the basal iodide content of the gastrointestinal tract. The resulting reactive iodine species readily attaches to organic matter by covalent bonding. Evidence suggests that the extent to which such iodinated organics are formed is proportional to the magnitude of the electromotive force and stoichiometry of the redox couple between iodide and the disinfectant. Because the extent of thyroid uptake of the bioavailable iodide does not decrease during ClO2 ingestion, it seems that ClO2 does not cause iodide deficiency of sufficient magnitude to account for the decrease in hormonogenesis. Absorption of one or more of iodinated molecules, e.g., nutrients, hormones, or cellular constituents of the alimentary tract having thyromimetic or thyroid inhibitory properties, is a better hypothesis for the effects seen. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/3816729/Mechanistic_aspects_of_ingested_chlorine_dioxide_on_thyroid_function:_impact_of_oxidants_on_iodide_metabolism_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.8669249?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -