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Parasympathetic assessment in Parkinson's disease.
Adv Neurol. 1987; 45:267-9.AN

Abstract

There is little evidence of autonomic dysfunction in PD, although autonomic disturbance was included in the original description by J. Parkinson. In addition, there are no data for de novo PD patients. We selected 14 de novo parkinsonians (seven men and seven women), aged 62.7 +/- 8.2 years, with mild disease (stage 1 through 2 on the Hoehn and Yahr's scale), without history of diabetes, heart disease, or alcoholism, and without neuropathy or orthostatic hypotension. Fourteen age- and sex-matched normal persons were controls. We found a highly significant difference in the respiratory sinus arrhythmias during deep breathing (p less than 0.01); the basal heart rate, the respiratory sinus arrhythmias during quiet breathing, and the Valsalva ratios did not differ statistically, however. In the absence of neuropathy and orthostatic hypotension and in the presence of normal Valsalva ratios, we believe that the abnormality found by us may apply only to parasympathetic dysfunction, perhaps at a central level. In addition, the abnormality seems to be independent of stage and therapy.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3825699

Citation

Camerlingo, M, et al. "Parasympathetic Assessment in Parkinson's Disease." Advances in Neurology, vol. 45, 1987, pp. 267-9.
Camerlingo M, Aillon C, Bottacchi E, et al. Parasympathetic assessment in Parkinson's disease. Adv Neurol. 1987;45:267-9.
Camerlingo, M., Aillon, C., Bottacchi, E., Gambaro, P., D'Alessandro, G., Franceschi, M., Devoti, G., & Mamoli, A. (1987). Parasympathetic assessment in Parkinson's disease. Advances in Neurology, 45, 267-9.
Camerlingo M, et al. Parasympathetic Assessment in Parkinson's Disease. Adv Neurol. 1987;45:267-9. PubMed PMID: 3825699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parasympathetic assessment in Parkinson's disease. AU - Camerlingo,M, AU - Aillon,C, AU - Bottacchi,E, AU - Gambaro,P, AU - D'Alessandro,G, AU - Franceschi,M, AU - Devoti,G, AU - Mamoli,A, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 267 EP - 9 JF - Advances in neurology JO - Adv Neurol VL - 45 N2 - There is little evidence of autonomic dysfunction in PD, although autonomic disturbance was included in the original description by J. Parkinson. In addition, there are no data for de novo PD patients. We selected 14 de novo parkinsonians (seven men and seven women), aged 62.7 +/- 8.2 years, with mild disease (stage 1 through 2 on the Hoehn and Yahr's scale), without history of diabetes, heart disease, or alcoholism, and without neuropathy or orthostatic hypotension. Fourteen age- and sex-matched normal persons were controls. We found a highly significant difference in the respiratory sinus arrhythmias during deep breathing (p less than 0.01); the basal heart rate, the respiratory sinus arrhythmias during quiet breathing, and the Valsalva ratios did not differ statistically, however. In the absence of neuropathy and orthostatic hypotension and in the presence of normal Valsalva ratios, we believe that the abnormality found by us may apply only to parasympathetic dysfunction, perhaps at a central level. In addition, the abnormality seems to be independent of stage and therapy. SN - 0091-3952 UR - https://www.unboundmedicine.com/medline/citation/3825699/Parasympathetic_assessment_in_Parkinson's_disease_ L2 - https://www.diseaseinfosearch.org/result/5603 DB - PRIME DP - Unbound Medicine ER -