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Cardiovascular lesions in cobalt-vitamin B12 deficient sheep.
Ann Rech Vet. 1986; 17(4):447-50.AR

Abstract

Cardiovascular lesions were observed at necropsy in five of six sheep which were subjected to an experimentally induced cobalt-vitamin B12 deficiency during a period of 34 weeks. The classical symptoms of cobalt-vitamin B12 deficiency (anorexia, cachexia, anaemia) were seen in all six sheep at week 20 of the experiment. Histologically, lesions of the auricular epicardium and myocardium consisted of a high concentration of inflammatory cells dominated by polynuclear eosinophils as well as the haemorrhagic inflammation of blood vessels accompanied by necrosis of auricular tissue. The similarity between the lesions observed in the present experiment and those seen in arteriosclerosis, led to the suggestion that a deficiency of vitamin B12 may be implicated in the pathogenesis of arteriosclerosis. A hypothesis is advanced in this respect.

Authors

Mohammed R
No affiliation info available
Lamand M
No affiliation info available

MeSH

AnimalsArteriosclerosisCardiovascular DiseasesCobaltMyocardiumNecrosisSheepSheep DiseasesVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3827146

Citation

Mohammed, R, and M Lamand. "Cardiovascular Lesions in Cobalt-vitamin B12 Deficient Sheep." Annales De Recherches Veterinaires. Annals of Veterinary Research, vol. 17, no. 4, 1986, pp. 447-50.
Mohammed R, Lamand M. Cardiovascular lesions in cobalt-vitamin B12 deficient sheep. Ann Rech Vet. 1986;17(4):447-50.
Mohammed, R., & Lamand, M. (1986). Cardiovascular lesions in cobalt-vitamin B12 deficient sheep. Annales De Recherches Veterinaires. Annals of Veterinary Research, 17(4), 447-50.
Mohammed R, Lamand M. Cardiovascular Lesions in Cobalt-vitamin B12 Deficient Sheep. Ann Rech Vet. 1986;17(4):447-50. PubMed PMID: 3827146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular lesions in cobalt-vitamin B12 deficient sheep. AU - Mohammed,R, AU - Lamand,M, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 447 EP - 50 JF - Annales de recherches veterinaires. Annals of veterinary research JO - Ann Rech Vet VL - 17 IS - 4 N2 - Cardiovascular lesions were observed at necropsy in five of six sheep which were subjected to an experimentally induced cobalt-vitamin B12 deficiency during a period of 34 weeks. The classical symptoms of cobalt-vitamin B12 deficiency (anorexia, cachexia, anaemia) were seen in all six sheep at week 20 of the experiment. Histologically, lesions of the auricular epicardium and myocardium consisted of a high concentration of inflammatory cells dominated by polynuclear eosinophils as well as the haemorrhagic inflammation of blood vessels accompanied by necrosis of auricular tissue. The similarity between the lesions observed in the present experiment and those seen in arteriosclerosis, led to the suggestion that a deficiency of vitamin B12 may be implicated in the pathogenesis of arteriosclerosis. A hypothesis is advanced in this respect. SN - 0003-4193 UR - https://www.unboundmedicine.com/medline/citation/3827146/Cardiovascular_lesions_in_cobalt_vitamin_B12_deficient_sheep_ DB - PRIME DP - Unbound Medicine ER -