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[Antagonism of piracetam with proline in relation to mnestic effects].
Biull Eksp Biol Med. 1985 Mar; 99(3):311-4.BE

Abstract

Based on the authors' previous data showing that the lipophylic cethyl group promotes the penetration of amino acids through the blood-brain barrier, proline cethyl ester was synthesized and studied as a neuropharmacological tool. The substance administered to rats systemically (intraperitoneally) was shown to be able to provoke a deep amnesia when tested by the conditioned avoidance performance. Piracetam abolished the amnestic effect of proline cethyl ester while sodium hydroxybutyrate administered in the dosage range provoking the nootropic effect did not change that amnesia. The data suggest that proline may be considered as one of the possible endogenous amnestic factors. The close structural similarity of the piracetam cyclic fragment to proline, which resulted in their competition, appears to be one of the reasons for piracetam antiamnestic activity.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

3838687

Citation

Ostrovskaia, R U., et al. "[Antagonism of Piracetam With Proline in Relation to Mnestic Effects]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 99, no. 3, 1985, pp. 311-4.
Ostrovskaia RU, Trofimov SS, Tsybina NM, et al. [Antagonism of piracetam with proline in relation to mnestic effects]. Biull Eksp Biol Med. 1985;99(3):311-4.
Ostrovskaia, R. U., Trofimov, S. S., Tsybina, N. M., Gudasheva, T. A., & Skoldinov, A. P. (1985). [Antagonism of piracetam with proline in relation to mnestic effects]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 99(3), 311-4.
Ostrovskaia RU, et al. [Antagonism of Piracetam With Proline in Relation to Mnestic Effects]. Biull Eksp Biol Med. 1985;99(3):311-4. PubMed PMID: 3838687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antagonism of piracetam with proline in relation to mnestic effects]. AU - Ostrovskaia,R U, AU - Trofimov,S S, AU - Tsybina,N M, AU - Gudasheva,T A, AU - Skoldinov,A P, PY - 1985/3/1/pubmed PY - 1985/3/1/medline PY - 1985/3/1/entrez SP - 311 EP - 4 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 99 IS - 3 N2 - Based on the authors' previous data showing that the lipophylic cethyl group promotes the penetration of amino acids through the blood-brain barrier, proline cethyl ester was synthesized and studied as a neuropharmacological tool. The substance administered to rats systemically (intraperitoneally) was shown to be able to provoke a deep amnesia when tested by the conditioned avoidance performance. Piracetam abolished the amnestic effect of proline cethyl ester while sodium hydroxybutyrate administered in the dosage range provoking the nootropic effect did not change that amnesia. The data suggest that proline may be considered as one of the possible endogenous amnestic factors. The close structural similarity of the piracetam cyclic fragment to proline, which resulted in their competition, appears to be one of the reasons for piracetam antiamnestic activity. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/3838687/[Antagonism_of_piracetam_with_proline_in_relation_to_mnestic_effects]_ DB - PRIME DP - Unbound Medicine ER -