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Behçet's syndrome. Immunopathologic and histopathologic assessment of pathergy lesions is useful in diagnosis and follow-up.
Arch Pathol Lab Med. 1985 Aug; 109(8):747-51.AP

Abstract

Behçet's syndrome is a complex multisystem disease that, due to the absence of a pathognomonic laboratory test, must be diagnosed using clinical criteria. Clinical pathergy testing, the induction of a sterile pustule 24 hours after cutaneous trauma, has been proposed as a useful adjunct to diagnosis. We have expanded this concept by showing the usefulness of examining pathergy lesions by routine and immunofluorescence microscopy in the diagnosis of nine patients with Behçet's syndrome. Furthermore, histopathologic pathergy assessments correlated with clinical disease activity and/or response to experimental oral thalidomide therapy in five of six patients with Behçet's syndrome who were retested.

Authors

Jorizzo JL
No affiliation info available
Solomon AR
No affiliation info available
Cavallo T
No affiliation info available

MeSH

AdultBehcet SyndromeFemaleHumansMaleMiddle AgedSkinSkin TestsThalidomideTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3839376

Citation

Jorizzo, J L., et al. "Behçet's Syndrome. Immunopathologic and Histopathologic Assessment of Pathergy Lesions Is Useful in Diagnosis and Follow-up." Archives of Pathology & Laboratory Medicine, vol. 109, no. 8, 1985, pp. 747-51.
Jorizzo JL, Solomon AR, Cavallo T. Behçet's syndrome. Immunopathologic and histopathologic assessment of pathergy lesions is useful in diagnosis and follow-up. Arch Pathol Lab Med. 1985;109(8):747-51.
Jorizzo, J. L., Solomon, A. R., & Cavallo, T. (1985). Behçet's syndrome. Immunopathologic and histopathologic assessment of pathergy lesions is useful in diagnosis and follow-up. Archives of Pathology & Laboratory Medicine, 109(8), 747-51.
Jorizzo JL, Solomon AR, Cavallo T. Behçet's Syndrome. Immunopathologic and Histopathologic Assessment of Pathergy Lesions Is Useful in Diagnosis and Follow-up. Arch Pathol Lab Med. 1985;109(8):747-51. PubMed PMID: 3839376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behçet's syndrome. Immunopathologic and histopathologic assessment of pathergy lesions is useful in diagnosis and follow-up. AU - Jorizzo,J L, AU - Solomon,A R, AU - Cavallo,T, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 747 EP - 51 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 109 IS - 8 N2 - Behçet's syndrome is a complex multisystem disease that, due to the absence of a pathognomonic laboratory test, must be diagnosed using clinical criteria. Clinical pathergy testing, the induction of a sterile pustule 24 hours after cutaneous trauma, has been proposed as a useful adjunct to diagnosis. We have expanded this concept by showing the usefulness of examining pathergy lesions by routine and immunofluorescence microscopy in the diagnosis of nine patients with Behçet's syndrome. Furthermore, histopathologic pathergy assessments correlated with clinical disease activity and/or response to experimental oral thalidomide therapy in five of six patients with Behçet's syndrome who were retested. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/3839376/Behçet's_syndrome__Immunopathologic_and_histopathologic_assessment_of_pathergy_lesions_is_useful_in_diagnosis_and_follow_up_ DB - PRIME DP - Unbound Medicine ER -