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Vasoactive intestinal peptide as a possible transmitter of nonadrenergic, noncholinergic relaxation of pulmonary artery.
Trans Assoc Am Physicians. 1985; 98:233-42.TA

Abstract

Electrical field stimulation of isolated guinea pig pulmonary artery induced a brief initial contraction followed by a more prolonged relaxation. alpha-Adrenergic blockade prevented the contraction and enhanced the relaxation. beta-Adrenergic and cholinergic muscarinic blockade partially reduced the relaxation, but 44.4% of the relaxation persisted after adrenergic and cholinergic blockade. The PA relaxation was associated with the release of immunoreactive VIP, both before and after this blockade. Tetrodotoxin abolished the nonadrenergic, noncholinergic relaxation and markedly reduced the release of VIP. This relaxation was similarly attenuated by a monoclonal antibody against VIP.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3842197

Citation

Kubota, E, et al. "Vasoactive Intestinal Peptide as a Possible Transmitter of Nonadrenergic, Noncholinergic Relaxation of Pulmonary Artery." Transactions of the Association of American Physicians, vol. 98, 1985, pp. 233-42.
Kubota E, Sata T, Soas AH, et al. Vasoactive intestinal peptide as a possible transmitter of nonadrenergic, noncholinergic relaxation of pulmonary artery. Trans Assoc Am Physicians. 1985;98:233-42.
Kubota, E., Sata, T., Soas, A. H., Paul, S., & Said, S. I. (1985). Vasoactive intestinal peptide as a possible transmitter of nonadrenergic, noncholinergic relaxation of pulmonary artery. Transactions of the Association of American Physicians, 98, 233-42.
Kubota E, et al. Vasoactive Intestinal Peptide as a Possible Transmitter of Nonadrenergic, Noncholinergic Relaxation of Pulmonary Artery. Trans Assoc Am Physicians. 1985;98:233-42. PubMed PMID: 3842197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasoactive intestinal peptide as a possible transmitter of nonadrenergic, noncholinergic relaxation of pulmonary artery. AU - Kubota,E, AU - Sata,T, AU - Soas,A H, AU - Paul,S, AU - Said,S I, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 233 EP - 42 JF - Transactions of the Association of American Physicians JO - Trans. Assoc. Am. Physicians VL - 98 N2 - Electrical field stimulation of isolated guinea pig pulmonary artery induced a brief initial contraction followed by a more prolonged relaxation. alpha-Adrenergic blockade prevented the contraction and enhanced the relaxation. beta-Adrenergic and cholinergic muscarinic blockade partially reduced the relaxation, but 44.4% of the relaxation persisted after adrenergic and cholinergic blockade. The PA relaxation was associated with the release of immunoreactive VIP, both before and after this blockade. Tetrodotoxin abolished the nonadrenergic, noncholinergic relaxation and markedly reduced the release of VIP. This relaxation was similarly attenuated by a monoclonal antibody against VIP. SN - 0066-9458 UR - https://www.unboundmedicine.com/medline/citation/3842197/Vasoactive_intestinal_peptide_as_a_possible_transmitter_of_nonadrenergic_noncholinergic_relaxation_of_pulmonary_artery_ DB - PRIME DP - Unbound Medicine ER -