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Prolonged amenorrhea and oral contraceptives.
Fertil Steril. 1979 Sep; 32(3):265-8.FS

Abstract

Of 106 consecutive women referred for secondary amenorrhea of more than 1 year's duration, 65 were diagnosed as having functional amenorrhea. Of these 65, 29 had amenorrhea directly following discontinuation of oral contraceptives (OC group) and 36 had never used oral contraceptives (NOC group). There was no difference in the incidence of prior menstrual irregularity in either group. Similarly, there was no difference in the resting serum estrone, estradiol, luteinizing hormone, follicle-stimulating hormone, and prolactin levels between the OC and NOC groups. Nor was there a difference between the OC and NOC groups in response to medroxyprogesterone acetate, clomiphene citrate, or luteinizing hormone-releasing factor. Of 106 patients, 17 were proven to have prolactinomas. Eight patients had a prior history of OC use, whereas nine did not. With the exception of elevated serum prolactin levels, there were no significant differences in biochemical tests or history of oral contraceptive use between the prolactinoma group and patients with prolonged "functional" amenorrhea (OC plus NOC groups). The lack of historical or biochemical difference between the OC and NOC subjects indicates homogeneity between groups, and does not support the existence of a "postpill" syndrome.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

385358

Citation

Tolis, G, et al. "Prolonged Amenorrhea and Oral Contraceptives." Fertility and Sterility, vol. 32, no. 3, 1979, pp. 265-8.
Tolis G, Ruggere D, Popkin DR, et al. Prolonged amenorrhea and oral contraceptives. Fertil Steril. 1979;32(3):265-8.
Tolis, G., Ruggere, D., Popkin, D. R., Chow, J., Boyd, M. E., De Leon, A., Lalonde, A. B., Asswad, A., Hendelman, M., Scali, V., Koby, R., Arronet, G., Yufe, B., Tweedie, F. J., Fournier, P. R., & Naftolin, F. (1979). Prolonged amenorrhea and oral contraceptives. Fertility and Sterility, 32(3), 265-8.
Tolis G, et al. Prolonged Amenorrhea and Oral Contraceptives. Fertil Steril. 1979;32(3):265-8. PubMed PMID: 385358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged amenorrhea and oral contraceptives. AU - Tolis,G, AU - Ruggere,D, AU - Popkin,D R, AU - Chow,J, AU - Boyd,M E, AU - De Leon,A, AU - Lalonde,A B, AU - Asswad,A, AU - Hendelman,M, AU - Scali,V, AU - Koby,R, AU - Arronet,G, AU - Yufe,B, AU - Tweedie,F J, AU - Fournier,P R, AU - Naftolin,F, PY - 1979/9/1/pubmed PY - 1979/9/1/medline PY - 1979/9/1/entrez KW - Amenorrhea KW - Americas KW - Canada KW - Comparative Studies KW - Contraception KW - Contraceptive Methods--side effects KW - Developed Countries KW - Diseases KW - Family Planning KW - Menstruation Disorders KW - North America KW - Northern America KW - Oral Contraceptives--side effects KW - Research Methodology KW - Studies SP - 265 EP - 8 JF - Fertility and sterility JO - Fertil Steril VL - 32 IS - 3 N2 - Of 106 consecutive women referred for secondary amenorrhea of more than 1 year's duration, 65 were diagnosed as having functional amenorrhea. Of these 65, 29 had amenorrhea directly following discontinuation of oral contraceptives (OC group) and 36 had never used oral contraceptives (NOC group). There was no difference in the incidence of prior menstrual irregularity in either group. Similarly, there was no difference in the resting serum estrone, estradiol, luteinizing hormone, follicle-stimulating hormone, and prolactin levels between the OC and NOC groups. Nor was there a difference between the OC and NOC groups in response to medroxyprogesterone acetate, clomiphene citrate, or luteinizing hormone-releasing factor. Of 106 patients, 17 were proven to have prolactinomas. Eight patients had a prior history of OC use, whereas nine did not. With the exception of elevated serum prolactin levels, there were no significant differences in biochemical tests or history of oral contraceptive use between the prolactinoma group and patients with prolonged "functional" amenorrhea (OC plus NOC groups). The lack of historical or biochemical difference between the OC and NOC subjects indicates homogeneity between groups, and does not support the existence of a "postpill" syndrome. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/385358/Prolonged_amenorrhea_and_oral_contraceptives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)44230-5 DB - PRIME DP - Unbound Medicine ER -