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Factor B (Bf) and glyoxalase genes in insulin-dependent diabetes mellitus.
Diabete Metab. 1985 Feb; 11(1):22-6.DM

Abstract

The frequency distribution of alleles controlled by the factor B (Bf) and glyoxalase genes that are found close to the HLA system on chromosome 6 was studied in 170 insulin-dependent diabetic patients. The data were compared with those for HLA-A, -B and -DR antigens and were related to age of onset of diabetes. All the diabetics were ketosis prone and on permanent insulin therapy. A significant excess of BfF1 was seen in the diabetic patients (p less than 10(-4]. Glyoxalase frequency distribution showed no significant deviation from controls, whereas HLA-DR3 (p less than 10(-4] HLA-DR4 (p less than 10(-4] were increased. Breakdown of data by age of diagnosis of disease showed no increase in the frequency of BfF1 and GLO1-2 but an increase of HLA DR3 and DR4 in patients with early onset diabetes. The findings of the study are consistent with data reported by others investigators and support the notion that one or more genes mapping close to the HLA A. B and DR and to the Bf loci confer susceptibility to insulin dependent diabetes.

Authors

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Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3856541

Citation

Allannic, H, et al. "Factor B (Bf) and Glyoxalase Genes in Insulin-dependent Diabetes Mellitus." Diabete & Metabolisme, vol. 11, no. 1, 1985, pp. 22-6.
Allannic H, Fauchet R, Gueguen M, et al. Factor B (Bf) and glyoxalase genes in insulin-dependent diabetes mellitus. Diabete Metab. 1985;11(1):22-6.
Allannic, H., Fauchet, R., Gueguen, M., Pheng Savath, H., Dinh Knoi, T., & Genetet, B. (1985). Factor B (Bf) and glyoxalase genes in insulin-dependent diabetes mellitus. Diabete & Metabolisme, 11(1), 22-6.
Allannic H, et al. Factor B (Bf) and Glyoxalase Genes in Insulin-dependent Diabetes Mellitus. Diabete Metab. 1985;11(1):22-6. PubMed PMID: 3856541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factor B (Bf) and glyoxalase genes in insulin-dependent diabetes mellitus. AU - Allannic,H, AU - Fauchet,R, AU - Gueguen,M, AU - Pheng Savath,H, AU - Dinh Knoi,T, AU - Genetet,B, PY - 1985/2/1/pubmed PY - 2000/3/11/medline PY - 1985/2/1/entrez SP - 22 EP - 6 JF - Diabete & metabolisme JO - Diabete Metab VL - 11 IS - 1 N2 - The frequency distribution of alleles controlled by the factor B (Bf) and glyoxalase genes that are found close to the HLA system on chromosome 6 was studied in 170 insulin-dependent diabetic patients. The data were compared with those for HLA-A, -B and -DR antigens and were related to age of onset of diabetes. All the diabetics were ketosis prone and on permanent insulin therapy. A significant excess of BfF1 was seen in the diabetic patients (p less than 10(-4]. Glyoxalase frequency distribution showed no significant deviation from controls, whereas HLA-DR3 (p less than 10(-4] HLA-DR4 (p less than 10(-4] were increased. Breakdown of data by age of diagnosis of disease showed no increase in the frequency of BfF1 and GLO1-2 but an increase of HLA DR3 and DR4 in patients with early onset diabetes. The findings of the study are consistent with data reported by others investigators and support the notion that one or more genes mapping close to the HLA A. B and DR and to the Bf loci confer susceptibility to insulin dependent diabetes. SN - 0338-1684 UR - https://www.unboundmedicine.com/medline/citation/3856541/Factor_B__Bf__and_glyoxalase_genes_in_insulin_dependent_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -