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[Glomerulopathy during Behçet's syndrome. Immunofluorescent and electron microscopy studies (author's transl)].
Ann Med Interne (Paris). 1979; 130(8-9):393-9.AM

Abstract

Full renal investigation were conducted in 11 patients with Behçet's syndrome. Biological tests revealed the presence of mild proteinuria in 5 of them. Needle biopsy showed extra-membranous or mesangial fibrinoid deposits in 6 cases, associated in 1 case with segmental and focal glomerulitis lesions. Immunofluorescence studies demonstrated glomerular deposits of mesangial and extra-membranous C3, sometimes with immunoglobulins (IgA-AgG). Ultrastructural examination was carried out in 7 cases and showed "hump" deposits attached to the external face of the basal membrane and rounded nodules of 7 to 15 mu included in the mesangium. The presence of immune complexes in the renal glomeruli, therefore, is not all unusual in this disease, which is probably auto-immune in nature, and in fact appears to be a quite frequent occurrence. These deposits, which were probably well-tolerated by most of the patients in this series, might be involved in the production of progressive glomerulopathies in chronic cases, as observed in one of the cases studied.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

386868

Citation

Auriol, M, et al. "[Glomerulopathy During Behçet's Syndrome. Immunofluorescent and Electron Microscopy Studies (author's Transl)]." Annales De Medecine Interne, vol. 130, no. 8-9, 1979, pp. 393-9.
Auriol M, Beaufils H, Herreman G, et al. [Glomerulopathy during Behçet's syndrome. Immunofluorescent and electron microscopy studies (author's transl)]. Ann Med Interne (Paris). 1979;130(8-9):393-9.
Auriol, M., Beaufils, H., Herreman, G., Tranbaloc, P., Wechsler, B., Godeau, P., & Chomette, G. (1979). [Glomerulopathy during Behçet's syndrome. Immunofluorescent and electron microscopy studies (author's transl)]. Annales De Medecine Interne, 130(8-9), 393-9.
Auriol M, et al. [Glomerulopathy During Behçet's Syndrome. Immunofluorescent and Electron Microscopy Studies (author's Transl)]. Ann Med Interne (Paris). 1979;130(8-9):393-9. PubMed PMID: 386868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Glomerulopathy during Behçet's syndrome. Immunofluorescent and electron microscopy studies (author's transl)]. AU - Auriol,M, AU - Beaufils,H, AU - Herreman,G, AU - Tranbaloc,P, AU - Wechsler,B, AU - Godeau,P, AU - Chomette,G, PY - 1979/1/1/pubmed PY - 1979/1/1/medline PY - 1979/1/1/entrez SP - 393 EP - 9 JF - Annales de medecine interne JO - Ann Med Interne (Paris) VL - 130 IS - 8-9 N2 - Full renal investigation were conducted in 11 patients with Behçet's syndrome. Biological tests revealed the presence of mild proteinuria in 5 of them. Needle biopsy showed extra-membranous or mesangial fibrinoid deposits in 6 cases, associated in 1 case with segmental and focal glomerulitis lesions. Immunofluorescence studies demonstrated glomerular deposits of mesangial and extra-membranous C3, sometimes with immunoglobulins (IgA-AgG). Ultrastructural examination was carried out in 7 cases and showed "hump" deposits attached to the external face of the basal membrane and rounded nodules of 7 to 15 mu included in the mesangium. The presence of immune complexes in the renal glomeruli, therefore, is not all unusual in this disease, which is probably auto-immune in nature, and in fact appears to be a quite frequent occurrence. These deposits, which were probably well-tolerated by most of the patients in this series, might be involved in the production of progressive glomerulopathies in chronic cases, as observed in one of the cases studied. SN - 0003-410X UR - https://www.unboundmedicine.com/medline/citation/386868/[Glomerulopathy_during_Behçet's_syndrome__Immunofluorescent_and_electron_microscopy_studies__author's_transl_]_ L2 - https://medlineplus.gov/behcetssyndrome.html DB - PRIME DP - Unbound Medicine ER -