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Treatment of venereal disease in the penicillin-allergic patient: administration of penicillin following testing with major and minor determinants.
N Engl Reg Allergy Proc. 1985 Spring; 6(2):166-9.NE

Abstract

We describe the administration of penicillin for venereal disease in three penicillin-allergic patients for whom alternative antibiotics were not considered suitable. Each patient was skin test negative to the major penicillin determinant benzylpenicilloyl-polylysine and a minor determinant mixture of potassium penicillin, benzylpenicilloate and benzylpenicilloyl-n-propylamine provided by the National Institute of Allergy and Infectious Diseases. Therapeutic doses of penicillin were administered without anaphylaxis, but one patient developed serum sickness on day five following benzylpenicillin. The skin testing results were determined within 30 minutes such that penicillin or its derivatives could be administered safely and rapidly to seriously ill patients, i.e. disseminated gonococcemia. When treating neurosyphilis or disseminated gonococcal infection for which non-penicillin therapy is unacceptable, use of the current skin test reagents provides a level of safety in avoiding anaphylaxis not previously attainable.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3870499

Citation

Greenberger, P A., and J P. Phair. "Treatment of Venereal Disease in the Penicillin-allergic Patient: Administration of Penicillin Following Testing With Major and Minor Determinants." New England and Regional Allergy Proceedings, vol. 6, no. 2, 1985, pp. 166-9.
Greenberger PA, Phair JP. Treatment of venereal disease in the penicillin-allergic patient: administration of penicillin following testing with major and minor determinants. N Engl Reg Allergy Proc. 1985;6(2):166-9.
Greenberger, P. A., & Phair, J. P. (1985). Treatment of venereal disease in the penicillin-allergic patient: administration of penicillin following testing with major and minor determinants. New England and Regional Allergy Proceedings, 6(2), 166-9.
Greenberger PA, Phair JP. Treatment of Venereal Disease in the Penicillin-allergic Patient: Administration of Penicillin Following Testing With Major and Minor Determinants. N Engl Reg Allergy Proc. 1985;6(2):166-9. PubMed PMID: 3870499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of venereal disease in the penicillin-allergic patient: administration of penicillin following testing with major and minor determinants. AU - Greenberger,P A, AU - Phair,J P, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 166 EP - 9 JF - New England and regional allergy proceedings JO - N Engl Reg Allergy Proc VL - 6 IS - 2 N2 - We describe the administration of penicillin for venereal disease in three penicillin-allergic patients for whom alternative antibiotics were not considered suitable. Each patient was skin test negative to the major penicillin determinant benzylpenicilloyl-polylysine and a minor determinant mixture of potassium penicillin, benzylpenicilloate and benzylpenicilloyl-n-propylamine provided by the National Institute of Allergy and Infectious Diseases. Therapeutic doses of penicillin were administered without anaphylaxis, but one patient developed serum sickness on day five following benzylpenicillin. The skin testing results were determined within 30 minutes such that penicillin or its derivatives could be administered safely and rapidly to seriously ill patients, i.e. disseminated gonococcemia. When treating neurosyphilis or disseminated gonococcal infection for which non-penicillin therapy is unacceptable, use of the current skin test reagents provides a level of safety in avoiding anaphylaxis not previously attainable. SN - 0742-2814 UR - https://www.unboundmedicine.com/medline/citation/3870499/Treatment_of_venereal_disease_in_the_penicillin-allergic_patient:_administration_of_penicillin_following_testing_with_major_and_minor_determinants L2 - https://medlineplus.gov/drugreactions.html DB - PRIME DP - Unbound Medicine ER -