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The clinical relevance of classes of immunoglobulins on spermatozoa from infertile and vasovasostomized males.
Fertil Steril. 1985 Apr; 43(4):621-7.FS

Abstract

Following reversal of vasectomy, conceptions occur even when antisperm antibodies are present in the seminal plasma, but this is most unusual in men with similar titers of such antibodies who are spontaneously infertile. To clarify the differences between antisperm antibodies occurring in infertile men and those associated with vasectomy reversal, we have studied 23 spontaneously infertile men and 22 men who underwent vasectomy reversal, all of whom had antisperm antibodies detected in seminal plasma by the same tray agglutination test. The class of antibody on spermatozoa was defined by a double-antibody technique using diluted rabbit anti-human IgG, IgM, or IgA or secretory component, followed, after washing, by 125I-labeled donkey anti-rabbit Ig. The results have shown that similar amounts of IgG and IgM were present on the spermatozoa, but infertile men had significantly more IgA and especially more secretory component than men who underwent vasectomy reversal. This was associated with significantly greater impairment of penetration of cervical mucus in the former group. It appears that the type of antibody on the spermatozoa may vary according to the stimulus for its production.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3872817

Citation

Parslow, J M., et al. "The Clinical Relevance of Classes of Immunoglobulins On Spermatozoa From Infertile and Vasovasostomized Males." Fertility and Sterility, vol. 43, no. 4, 1985, pp. 621-7.
Parslow JM, Poulton TA, Besser GM, et al. The clinical relevance of classes of immunoglobulins on spermatozoa from infertile and vasovasostomized males. Fertil Steril. 1985;43(4):621-7.
Parslow, J. M., Poulton, T. A., Besser, G. M., & Hendry, W. F. (1985). The clinical relevance of classes of immunoglobulins on spermatozoa from infertile and vasovasostomized males. Fertility and Sterility, 43(4), 621-7.
Parslow JM, et al. The Clinical Relevance of Classes of Immunoglobulins On Spermatozoa From Infertile and Vasovasostomized Males. Fertil Steril. 1985;43(4):621-7. PubMed PMID: 3872817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The clinical relevance of classes of immunoglobulins on spermatozoa from infertile and vasovasostomized males. AU - Parslow,J M, AU - Poulton,T A, AU - Besser,G M, AU - Hendry,W F, PY - 1985/4/1/pubmed PY - 1985/4/1/medline PY - 1985/4/1/entrez KW - Antibodies KW - Biology KW - Clinical Research KW - Diseases KW - Evaluation KW - Family Planning KW - Genitalia KW - Germ Cells KW - Hematological Effects KW - Hemic System KW - Immunity KW - Immunoglobulin Alterations KW - Immunologic Factors KW - Infertility--men KW - Male Sterilization KW - Physiology KW - Reproduction KW - Research Methodology KW - Reversibility KW - Spermatozoa KW - Sterilization, Sexual KW - Urogenital Effects KW - Urogenital System KW - Vasectomy SP - 621 EP - 7 JF - Fertility and sterility JO - Fertil Steril VL - 43 IS - 4 N2 - Following reversal of vasectomy, conceptions occur even when antisperm antibodies are present in the seminal plasma, but this is most unusual in men with similar titers of such antibodies who are spontaneously infertile. To clarify the differences between antisperm antibodies occurring in infertile men and those associated with vasectomy reversal, we have studied 23 spontaneously infertile men and 22 men who underwent vasectomy reversal, all of whom had antisperm antibodies detected in seminal plasma by the same tray agglutination test. The class of antibody on spermatozoa was defined by a double-antibody technique using diluted rabbit anti-human IgG, IgM, or IgA or secretory component, followed, after washing, by 125I-labeled donkey anti-rabbit Ig. The results have shown that similar amounts of IgG and IgM were present on the spermatozoa, but infertile men had significantly more IgA and especially more secretory component than men who underwent vasectomy reversal. This was associated with significantly greater impairment of penetration of cervical mucus in the former group. It appears that the type of antibody on the spermatozoa may vary according to the stimulus for its production. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/3872817/The_clinical_relevance_of_classes_of_immunoglobulins_on_spermatozoa_from_infertile_and_vasovasostomized_males_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)48507-9 DB - PRIME DP - Unbound Medicine ER -