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HLA-A, B, DR antigens and insulin-dependent diabetes in Algerians.
Tissue Antigens. 1985 Jul; 26(1):20-4.TA

Abstract

HLA-A, B and DR antigens have been investigated in insulin-dependent diabetics and compared to controls in a population of Algerians. A decrease of A1 and DR2 and an increase of Aw 19.2; B8, B18 and especially DR3 were found in diabetics in comparison to controls. The strongest association was found for DR3, which is a good genetic marker of IDD (RR = 8.50) in this population. The frequency of some HLA antigen associations in IDD suggests that the diabetic gene(s) is linked to 2 main haplotypes: Aw 19.2; B18; DR3 and Aw 19.2; B8; DR3. Antigen DR4 was equally represented in IDD (21%) and controls (28.4%), but heterozygote DR3-DR4 was more frequent in diabetics. The relation between IDD and HLA antigens found in the Algerian population is very similar to that described in diabetic Caucasian populations of southern Europe, except for the lack of association with DR4.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3875911

Citation

Mercier, P, et al. "HLA-A, B, DR Antigens and Insulin-dependent Diabetes in Algerians." Tissue Antigens, vol. 26, no. 1, 1985, pp. 20-4.
Mercier P, Vallo JJ, Vialettes B, et al. HLA-A, B, DR antigens and insulin-dependent diabetes in Algerians. Tissue Antigens. 1985;26(1):20-4.
Mercier, P., Vallo, J. J., Vialettes, B., & Vague, P. (1985). HLA-A, B, DR antigens and insulin-dependent diabetes in Algerians. Tissue Antigens, 26(1), 20-4.
Mercier P, et al. HLA-A, B, DR Antigens and Insulin-dependent Diabetes in Algerians. Tissue Antigens. 1985;26(1):20-4. PubMed PMID: 3875911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-A, B, DR antigens and insulin-dependent diabetes in Algerians. AU - Mercier,P, AU - Vallo,J J, AU - Vialettes,B, AU - Vague,P, PY - 1985/7/1/pubmed PY - 1985/7/1/medline PY - 1985/7/1/entrez SP - 20 EP - 4 JF - Tissue antigens JO - Tissue Antigens VL - 26 IS - 1 N2 - HLA-A, B and DR antigens have been investigated in insulin-dependent diabetics and compared to controls in a population of Algerians. A decrease of A1 and DR2 and an increase of Aw 19.2; B8, B18 and especially DR3 were found in diabetics in comparison to controls. The strongest association was found for DR3, which is a good genetic marker of IDD (RR = 8.50) in this population. The frequency of some HLA antigen associations in IDD suggests that the diabetic gene(s) is linked to 2 main haplotypes: Aw 19.2; B18; DR3 and Aw 19.2; B8; DR3. Antigen DR4 was equally represented in IDD (21%) and controls (28.4%), but heterozygote DR3-DR4 was more frequent in diabetics. The relation between IDD and HLA antigens found in the Algerian population is very similar to that described in diabetic Caucasian populations of southern Europe, except for the lack of association with DR4. SN - 0001-2815 UR - https://www.unboundmedicine.com/medline/citation/3875911/HLA_A_B_DR_antigens_and_insulin_dependent_diabetes_in_Algerians_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-2815&date=1985&volume=26&issue=1&spage=20 DB - PRIME DP - Unbound Medicine ER -