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Instability in the response to DST in major depressions during treatment with 5-hydroxytryptophan and carbidopa.
Acta Psychiatr Belg. 1985 May-Jun; 85(3):450-8.AP

Abstract

During the course of an investigation of predictors of the therapeutic response to a precursor of serotonin (5-hydroxytryptophan, 5-HTp) associated with carbidopa in major depressions with melancholia, patients, who before the treatment behaved as suppressors in the DST, became non-suppressors. The variation from non-suppressor to suppressor (which yielded in 60% of this sample) can be explained by the clinical improvement, but not the inverse change. In this paper, different possibilities on this change are analyzed, the most probable being the direct effect of the carbidopa in eminentia media. The carbidopa is administered because it is an inhibitor of the aminoacid decarboxylase, and since it does not cross the hematoencephalic barrier, it permits a better use of the 5-HTp. However, there is an exception: it does act in the cells of the eminentia media which, from the functional point of view, lie outside the above-mentioned hematoencephalic barrier.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3876688

Citation

Lopez-Ibor, J J., et al. "Instability in the Response to DST in Major Depressions During Treatment With 5-hydroxytryptophan and Carbidopa." Acta Psychiatrica Belgica, vol. 85, no. 3, 1985, pp. 450-8.
Lopez-Ibor JJ, Saiz-Ruiz J, Perez de los Cobos JC. Instability in the response to DST in major depressions during treatment with 5-hydroxytryptophan and carbidopa. Acta Psychiatr Belg. 1985;85(3):450-8.
Lopez-Ibor, J. J., Saiz-Ruiz, J., & Perez de los Cobos, J. C. (1985). Instability in the response to DST in major depressions during treatment with 5-hydroxytryptophan and carbidopa. Acta Psychiatrica Belgica, 85(3), 450-8.
Lopez-Ibor JJ, Saiz-Ruiz J, Perez de los Cobos JC. Instability in the Response to DST in Major Depressions During Treatment With 5-hydroxytryptophan and Carbidopa. Acta Psychiatr Belg. 1985 May-Jun;85(3):450-8. PubMed PMID: 3876688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Instability in the response to DST in major depressions during treatment with 5-hydroxytryptophan and carbidopa. AU - Lopez-Ibor,J J,Jr AU - Saiz-Ruiz,J, AU - Perez de los Cobos,J C, PY - 1985/5/1/pubmed PY - 2001/3/28/medline PY - 1985/5/1/entrez SP - 450 EP - 8 JF - Acta psychiatrica Belgica JO - Acta Psychiatr Belg VL - 85 IS - 3 N2 - During the course of an investigation of predictors of the therapeutic response to a precursor of serotonin (5-hydroxytryptophan, 5-HTp) associated with carbidopa in major depressions with melancholia, patients, who before the treatment behaved as suppressors in the DST, became non-suppressors. The variation from non-suppressor to suppressor (which yielded in 60% of this sample) can be explained by the clinical improvement, but not the inverse change. In this paper, different possibilities on this change are analyzed, the most probable being the direct effect of the carbidopa in eminentia media. The carbidopa is administered because it is an inhibitor of the aminoacid decarboxylase, and since it does not cross the hematoencephalic barrier, it permits a better use of the 5-HTp. However, there is an exception: it does act in the cells of the eminentia media which, from the functional point of view, lie outside the above-mentioned hematoencephalic barrier. SN - 0300-8967 UR - https://www.unboundmedicine.com/medline/citation/3876688/Instability_in_the_response_to_DST_in_major_depressions_during_treatment_with_5_hydroxytryptophan_and_carbidopa_ L2 - https://medlineplus.gov/bipolardisorder.html DB - PRIME DP - Unbound Medicine ER -